APAF1 and BCL2L10

Number of citations of the paper that reports this interaction (PubMedID 9878060)
37

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		APAF1	BCL2L10
Description		apoptotic peptidase activating factor 1	BCL2 like 10
Image
GO Annotations	Cellular Component	Extracellular Region Cytosol Protein-containing Complex Secretory Granule Lumen Apoptosome Extracellular Exosome Ficolin-1-rich Granule Lumen	Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Cytosol Membrane Integral Component Of Membrane Nuclear Membrane Mitochondria-associated Endoplasmic Reticulum Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Heat Shock Protein Binding Identical Protein Binding ADP Binding	Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Caspase Binding
	Biological Process	Response To Hypoxia Kidney Development Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nervous System Development Brain Development Aging Response To Nutrient Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Cardiac Muscle Cell Apoptotic Process Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To G1 DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Spermatogenesis Female Gamete Generation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Neutrophil degranulation TP53 Regulates Transcription of Caspase Activators and Caspases Transcriptional Regulation by E2F6 Regulation of the apoptosome activity Regulation of the apoptosome activity
Drugs		ATP
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172)
Interacting Genes		30 interacting genes: ACADS APIP AVEN BCL2L1 BCL2L10 CASP3 CASP4 CASP8 CASP9 CCL13 CDK17 CYCS DZIP1 ELK3 FAS FEM1B HIP1 HNF1A HSP90AA1 HSPA1A MRPL19 NLRP1 NR1H4 NUDT4 PAH PPP1CA RPL26L1 TOP1 TRIAP1 UTP20	16 interacting genes: APAF1 BAD BAK1 BAX BCL2 BCL2L1 BCL2L11 BECN1 BIK BMF CASP8 MGST2 NR4A1 SAMD4B TCF12 TMEM200A
Entrez ID		317	10017
HPRD ID		03755	06071
Ensembl ID		ENSG00000120868	ENSG00000137875
Uniprot IDs		O14727	H0YMD5 Q9HD36
PDB IDs		1C15 1CWW 1CY5 1Z6T 2P1H 2YGS 3J2T 3JBT 3YGS 4RHW 5JUY 5WVC 5WVE	4B4S
Enriched GO Terms of Interacting Partners?
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