HMGB2 and NAP1L1

Number of citations of the paper that reports this interaction (PubMedID 29721183)
4

Data Source:
BioGRID (two hybrid)

		HMGB2	NAP1L1
Description		high mobility group box 2	nucleosome assembly protein 1 like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Condensed Chromosome Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Protein-containing Complex Perinuclear Region Of Cytoplasm	Chromatin Nucleus Cytoplasm Membrane Melanosome
	Molecular Function	Four-way Junction DNA Binding Transcription Cis-regulatory Region Binding Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding DNA Binding, Bending Protein Domain Specific Binding Chemoattractant Activity Non-sequence-specific DNA Binding, Bending RAGE Receptor Binding Supercoiled DNA Binding	Chromatin Binding RNA Binding Protein Binding Histone Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Inflammatory Response To Antigenic Stimulus DNA Topological Change Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Nucleosome Assembly Regulation Of Transcription By RNA Polymerase II Spermatid Nucleus Differentiation Male Gonad Development Negative Regulation Of Gene Expression Positive Regulation Of Nuclease Activity DNA Geometric Change Response To Lipopolysaccharide Positive Regulation Of Interferon-beta Production V(D)J Recombination Positive Regulation Of DNA Binding Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Regulation Of Neurogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Chemotaxis Cell Chemotaxis Cellular Response To Lipopolysaccharide Regulation Of Stem Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	DNA Replication Nucleosome Assembly Positive Regulation Of Cell Population Proliferation Positive Regulation Of Neurogenesis Positive Regulation Of Neural Precursor Cell Proliferation
Pathways		Apoptosis induced DNA fragmentation
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189)
Interacting Genes		47 interacting genes: APEX1 APP AR ARCN1 C1QBP CACTIN CHAF1A COMMD1 CREBBP CSNK1A1 EIF1 FBXO7 FLNA GZMA GZMK H3-3A HACD3 HDLBP HMGA1 LZTS1 MIEN1 MYL6 NAP1L1 NCBP3 NEXN NOP53 NR3C1 PGR PKNOX1 POU2F1 POU2F2 POU3F1 POU5F1 PRKDC RAG1 RPS28 SAMM50 SET SNAPIN TERT TP53 TSNAX U2AF1 UHRF2 ZNF428 ZNF622 ZNF668	37 interacting genes: ANKRD23 C1QTNF9 CDK3 CES2 CHORDC1 CREBBP CSNK2A1 CSNK2B DLST EP300 ERCC6 FSD1 GAS2L2 H1-1 H3C1 H4C1 HBA1 HMGB2 HSPB1 KCNMB3 LINC01554 MED10 MTIF2 MTNR1A NAP1L2 NR2F6 OGT POT1 RPL23A RPS15 SP1 SUMO2 TERF1 TP53 TPX2 UBQLN2 ZDHHC17
Entrez ID		3148	4673
HPRD ID		01229	01248
Ensembl ID		ENSG00000164104	ENSG00000187109
Uniprot IDs		P26583	A0A024RBB7 B7Z2V4 F5H4R6 F8W543 P55209 Q9H2B0
PDB IDs
Enriched GO Terms of Interacting Partners?
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