HLA-DRB3 and MAP3K13

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		HLA-DRB3	MAP3K13
Description		major histocompatibility complex, class II, DR beta 3	mitogen-activated protein kinase kinase kinase 13
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Cytoplasm Membrane
	Molecular Function	Protein Binding MHC Class II Protein Complex Binding MHC Class II Receptor Activity Peptide Antigen Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Enzyme Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding IkappaB Kinase Complex Binding Protein Serine Kinase Activity
	Biological Process	Adaptive Immune Response Immunoglobulin Production Involved In Immunoglobulin-mediated Immune Response Myeloid Dendritic Cell Antigen Processing And Presentation Peptide Antigen Assembly With MHC Class II Protein Complex Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Signal Transduction Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation	Protein Phosphorylation JNK Cascade Positive Regulation Of Neuron Maturation Peptidyl-serine Phosphorylation Positive Regulation Of JUN Kinase Activity Positive Regulation Of Axon Extension Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Branching Morphogenesis Of A Nerve
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling
Drugs		1D09C3 Coccidioides immitis spherule	Fostamatinib
Diseases
GWAS		Plantar warts ( 28928442)	Airflow obstruction ( 22837378) Arterial stiffness index ( 31235810) Major depressive disorder ( 27519822) Neonatal white matter microstructure ( 33009551)
Interacting Genes		4 interacting genes: CDCA8 CTAG1B MAP3K13 POMC	9 interacting genes: CD44 GLO1 HLA-DRB3 IKBKB MAP2K7 MAPK8IP1 PRDX3 STAT3 TRIM25
Entrez ID		3125	9175
HPRD ID		09985	05372
Ensembl ID			ENSG00000073803
Uniprot IDs		A0A4D6G1L1 P79483	O43283
PDB IDs		2Q6W 3C5J 4H1L
Enriched GO Terms of Interacting Partners?
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