HIC1 and SENP3

Number of citations of the paper that reports this interaction (PubMedID 17283066)
62

Data Source:
BioGRID (enzymatic study)

		HIC1	SENP3
Description		HIC ZBTB transcriptional repressor 1	SUMO specific peptidase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm MLL1 Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding SUMO-specific Protease Activity SUMO-specific Isopeptidase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator	Protein Desumoylation
Pathways		SUMOylation of transcription factors	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Platelet count ( 27863252) Plateletcrit ( 32888494 27863252) Spleen volume ( 34128465)	Brain morphology (MOSTest) ( 32665545) IgM levels ( 23118916) Refractive error ( 32231278) Serum metabolite levels ( 33031748)
Interacting Genes		12 interacting genes: ARID1A CRBN CTBP1 CTBP2 HDAC1 HIC2 MECOM PIAS1 SENP3 SIRT1 TCF7L2 UBE2I	18 interacting genes: ADRB2 ATF7IP BECN1 CDCA8 CDK4 CDK6 CEP19 DNM1L EP300 HIC1 MDM2 NPM1 PARP1 SUMO2 TRIM54 TRIM63 USP15 USP21
Entrez ID		3090	26168
HPRD ID		04826	08339
Ensembl ID		ENSG00000177374	ENSG00000161956
Uniprot IDs		A0PJI1 Q14526	Q9H4L4
PDB IDs
Enriched GO Terms of Interacting Partners?
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