HIC1 and HIC2

Number of citations of the paper that reports this interaction (PubMedID 11554746)
13

Data Source:
BioGRID (two hybrid, imaging technique)

		HIC1	HIC2
Description		HIC ZBTB transcriptional repressor 1	HIC ZBTB transcriptional repressor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein C-terminus Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated
Pathways		SUMOylation of transcription factors
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Platelet count ( 27863252) Plateletcrit ( 32888494 27863252) Spleen volume ( 34128465)	Mean corpuscular volume ( 20139978) Systemic lupus erythematosus ( 19838193)
Interacting Genes		12 interacting genes: ARID1A CRBN CTBP1 CTBP2 HDAC1 HIC2 MECOM PIAS1 SENP3 SIRT1 TCF7L2 UBE2I	9 interacting genes: APP CCNT1 CEP70 CRBN EHMT2 HIC1 MFHAS1 PDK2 ZBTB8A
Entrez ID		3090	23119
HPRD ID		04826	07412
Ensembl ID		ENSG00000177374	ENSG00000169635
Uniprot IDs		A0PJI1 Q14526	Q96JB3
PDB IDs
Enriched GO Terms of Interacting Partners?
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