HCRTR1 and IFNGR2

		HCRTR1	IFNGR2
Description		hypocretin receptor 1	interferon gamma receptor 2
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Synapse	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane
	Molecular Function	G Protein-coupled Receptor Activity Orexin Receptor Activity Peptide Hormone Binding	Cytokine Receptor Activity Interferon-gamma Receptor Activity Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of ERK1 And ERK2 Cascade	Microglial Cell Activation Cell Surface Receptor Signaling Pathway Response To Virus Cytokine-mediated Signaling Pathway Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Positive Regulation Of NMDA Glutamate Receptor Activity
Pathways		Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events	Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Potential therapeutics for SARS
Drugs		Suvorexant Lemborexant	Interferon gamma-1b
Diseases
GWAS		Adiponectin levels ( 33562295) Asthma ( 31959851) Body mass index ( 26426971) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Daytime nap ( 33568662) General cognitive ability ( 29844566) Hypoalbuminemia ( 34050200)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 22936669 23128233) Diverticular disease ( 30177863) Educational attainment ( 25201988) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 31604244 24076602) Obesity-related traits ( 23251661) Psoriasis ( 25854761) Rheumatoid arthritis ( 30423114 24390342)
Interacting Genes		7 interacting genes: ARRB1 ARRB2 ATP1B1 CNR1 HCRT IFNGR2 PABPC4	46 interacting genes: ADIPOQ ANXA5 BNIP3 BRICD5 BTNL8 CAMK2D CCT8 CD302 CLDN19 CLEC7A CXCL9 DNAJA3 EMP3 ENTPD3 ERMP1 GIMAP5 GRIK1 HCRTR1 HLCS IFNG IFNGR1 INSIG2 JAGN1 JAK2 NR3C1 PMP22 RPL37A RTP2 SEC22B SFT2D2 SFTPC SLC52A1 SMIM3 STRIT1 TMEM120B TMEM140 TMEM199 TMEM218 TMEM254 TMEM60 TMEM97 TRARG1 TREX1 TSPAN2 UNC50 ZDHHC24
Entrez ID		3061	3460
HPRD ID		03863	00956
Ensembl ID		ENSG00000121764	ENSG00000159128
Uniprot IDs		A6NMV7 O43613	A8K881 E7EUY1 P38484
PDB IDs		4ZJ8 4ZJC 6TO7 6TOD 6TOS 6TOT 6TP3 6TP4 6TP6 6TQ4 6TQ6 6TQ7 6TQ9 6V9S	5EH1 6E3K 6E3L
Enriched GO Terms of Interacting Partners?
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