HCK and BCR

Number of citations of the paper that reports this interaction (PubMedID 12522270)
58

Data Source:
HPRD (in vivo)

		HCK	BCR
Description		HCK proto-oncogene, Src family tyrosine kinase	BCR activator of RhoGEF and GTPase
Image
GO Annotations	Cellular Component	Nucleus Lysosome Golgi Apparatus Cytosol Actin Filament Plasma Membrane Caveola Focal Adhesion Transport Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cell Projection Intracellular Membrane-bounded Organelle	Cytosol Membrane Axon Protein-containing Complex Dendritic Spine Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding	Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding ATP Binding Enzyme Binding Protein Serine Kinase Activity
	Biological Process	Leukocyte Migration Involved In Immune Response Innate Immune Response-activating Signal Transduction Negative Regulation Of Inflammatory Response To Antigenic Stimulus Protein Phosphorylation Inflammatory Response Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Mesoderm Development Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Positive Regulation Of Actin Filament Polymerization Lipopolysaccharide-mediated Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Apoptotic Process Leukocyte Degranulation Innate Immune Response Respiratory Burst After Phagocytosis Protein Autophosphorylation Regulation Of Inflammatory Response Regulation Of Phagocytosis Regulation Of DNA-binding Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Regulation Of Podosome Assembly Positive Regulation Of Actin Cytoskeleton Reorganization	Protein Phosphorylation Signal Transduction Small GTPase Mediated Signal Transduction Peptidyl-tyrosine Phosphorylation Keratinocyte Differentiation Regulation Of Rho Protein Signal Transduction Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Focal Adhesion Assembly Modulation Of Chemical Synaptic Transmission Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity
Pathways		Nef and signal transduction FCGR activation Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling FLT3 signaling through SRC family kinases	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs		1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Phosphonotyrosine Quercetin Bosutinib Fostamatinib	Imatinib Dasatinib Bosutinib Ponatinib
Diseases
GWAS		Adult body size ( 32376654) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Inflammatory bowel disease ( 23128233) Liver enzyme levels (alkaline phosphatase) ( 33972514) Migraine ( 27322543)	Asthma ( 27611488) Coenzyme Q10 levels ( 27149984) Height ( 18391951) Immune response to smallpox vaccine (IL-6) ( 22542470) Kidney stones ( 31729369) Left-handedness ( 32989287)
Interacting Genes		118 interacting genes: ABL1 ABL2 ACTB ADAM15 AGK AGR2 APP AR ARRB1 ASAP1 BCAR1 BCR BPIFA1 BTK CBL CCDC88B CCR3 CD2AP CHST15 COMT CREBBP CSF2RB CSF3R CSK CTAG1A CTAG1B CYB5D2 CYSRT1 DNM2 DOK1 DOK2 EGFR ELMO1 ERBB2 ERBB3 ERBB4 EVL FASLG FCGR1A FCGR2A FHL2 FHL5 GAB1 GOPC GRB14 HNRNPK HSF2BP IL6ST INCA1 INPP5D IRF2BPL KHDRBS1 KIT KPRP KRT31 KRT34 KRT35 KRT36 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-1 LCP2 LETMD1 LMNA MAP4K5 MDK MDM2 MET MID2 MKRN3 MTUS2 NBPF19 NGEF NOTCH2NLA PAK2 PECAM1 PIK3CB PIK3R1 PIK3R2 PLAUR PLCG1 PLCG2 PLEKHG4 PNMA1 PRRG4 RAPGEF1 RASA1 RASA3 RBPMS RPL10 SF3B3 SH2B2 SH3BP1 SH3KBP1 SKAP2 SOS1 SPRR2A STAT3 TEKT4 TEPSIN TNK2 TOX2 TP73 TRIM27 TRIP6 TRPV4 TSG101 UNC119 VAV1 WAS WDCP WIPF1 WNT2 ZSCAN4	45 interacting genes: ABL1 ABL2 AFDN APBA3 BLK CBL CDC42 CRK CRKL DLG1 DOK1 ERCC3 FES GRB10 GRB2 HCK HNF1A IGSF21 IRS1 JAK2 LNX1 MAP4K5 PLCG1 PTPN1 PTPN11 PTPN6 RAC1 RAD51 RASA1 RHOA SFN SHC1 SRC STUB1 TP53 TSG101 UBC UNC119 VAV1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		3055	613
HPRD ID		00796	01044
Ensembl ID		ENSG00000101336	ENSG00000186716
Uniprot IDs		A8K4G3 P08631	P11274
PDB IDs		1AD5 1BU1 1QCF 2C0I 2C0O 2C0T 2HCK 2HK5 2OI3 2OJ2 3HCK 3NHN 3RBB 3REA 3REB 3VRY 3VRZ 3VS0 3VS1 3VS2 3VS3 3VS4 3VS5 3VS6 3VS7 4HCK 4LUD 4LUE 4ORZ 4U5W 5H09 5H0B 5H0E 5H0G 5H0H 5HCK 5NUH 5ZJ6	1K1F 2AIN 5N6R 5N7E 5OC7
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?