BCR and APBA3

Number of citations of the paper that reports this interaction (PubMedID 15494376)
7

Data Source:
HPRD (in vitro, in vivo)

		BCR	APBA3
Description		BCR activator of RhoGEF and GTPase	amyloid beta precursor protein binding family A member 3
Image
GO Annotations	Cellular Component	Cytosol Membrane Axon Protein-containing Complex Dendritic Spine Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Cytoplasm Plasma Membrane Dendritic Spine Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding ATP Binding Enzyme Binding Protein Serine Kinase Activity	Amyloid-beta Binding Enzyme Inhibitor Activity Protein Binding Enzyme Binding
	Biological Process	Protein Phosphorylation Signal Transduction Small GTPase Mediated Signal Transduction Peptidyl-tyrosine Phosphorylation Keratinocyte Differentiation Regulation Of Rho Protein Signal Transduction Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Focal Adhesion Assembly Modulation Of Chemical Synaptic Transmission Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity	In Utero Embryonic Development Chemical Synaptic Transmission Regulation Of Gene Expression Protein Transport Negative Regulation Of Catalytic Activity
Pathways		Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle	Neurexins and neuroligins
Drugs		Imatinib Dasatinib Bosutinib Ponatinib
Diseases
GWAS		Asthma ( 27611488) Coenzyme Q10 levels ( 27149984) Height ( 18391951) Immune response to smallpox vaccine (IL-6) ( 22542470) Kidney stones ( 31729369) Left-handedness ( 32989287)	Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		45 interacting genes: ABL1 ABL2 AFDN APBA3 BLK CBL CDC42 CRK CRKL DLG1 DOK1 ERCC3 FES GRB10 GRB2 HCK HNF1A IGSF21 IRS1 JAK2 LNX1 MAP4K5 PLCG1 PTPN1 PTPN11 PTPN6 RAC1 RAD51 RASA1 RHOA SFN SHC1 SRC STUB1 TP53 TSG101 UBC UNC119 VAV1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	10 interacting genes: APP ARF3 ARF4 AZI2 BCR BDNF EGFR GPX4 TANK TBKBP1
Entrez ID		613	9546
HPRD ID		01044	05038
Ensembl ID		ENSG00000186716	ENSG00000011132
Uniprot IDs		P11274	O96018
PDB IDs		1K1F 2AIN 5N6R 5N7E 5OC7	2YT7 2YT8 5UWS
Enriched GO Terms of Interacting Partners?
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