H3-3A and BPTF

Number of citations of the paper that reports this interaction (PubMedID 16728976)
482

Data Source:
HPRD (in vitro)

		H3-3A	BPTF
Description		H3.3 histone A	bromodomain PHD finger transcription factor
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GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Nucleosome Extracellular Region Nucleus Nucleoplasm Protein-containing Complex Extracellular Exosome	Chromatin Nucleus Nucleoplasm Cytoplasm NURF Complex Dendrite Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Protein Binding Nucleosomal DNA Binding Protein Heterodimerization Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding ATP-dependent Activity, Acting On DNA Methylated Histone Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Positive Regulation Of Cell Growth Telomere Organization	Negative Regulation Of Transcription By RNA Polymerase II Embryonic Placenta Development Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Brain Development Endoderm Development Response To Wounding Anterior/posterior Pattern Specification Nucleosome Mobilization Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Nerve Growth Factor Stimulus
Pathways		Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Amyloid fiber formation Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alanine aminotransferase levels ( 33547301) Alcohol dependence symptom count ( 27151647) Apolipoprotein B levels ( 32203549) Body mass index ( 28892062) Brain morphology (MOSTest) ( 32665545) EGFR mutation-positive lung adenocarcinoma ( 27501781) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Hand grip strength ( 29691431) HDL cholesterol ( 30275531) Height ( 31562340) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Loneliness ( 31518406 29970889) Loneliness (MTAG) ( 29970889) Lung adenocarcinoma ( 22797724) Lung cancer ( 23143601) Macular thickness ( 30535121) Metabolic syndrome ( 31589552) Neutrophil percentage of granulocytes ( 27863252) Non-small cell lung cancer ( 31326317) Psoriasis ( 25854761) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258) Sum eosinophil basophil counts ( 27863252) Triglyceride levels ( 32203549 32154731 33339817) Type 2 diabetes ( 30297969) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		38 interacting genes: ASF1A ASF1B BPTF BRD7 CARM1 CHD1 CREBBP DCAF1 EP300 ESR1 HMGB2 HPF1 KAT2B KMT2A MAPK9 NEDD4 NOS3 PARP1 PARP10 PARP2 PELP1 PIM1 PPM1D PPP1CA PPP1CB SET SETD7 SMARCA1 SMARCA4 SMARCA5 SS18 SSRP1 SUPT16H SUV39H1 TLE2 UBN1 UHRF1 ZMYND11	10 interacting genes: H3-3A H3-4 H4C9 KEAP1 MAZ NFE2L2 SMAD2 SMAD3 SQSTM1 SUMO2
Entrez ID		3020	2186
HPRD ID		03082	03490
Ensembl ID		ENSG00000163041	ENSG00000171634
Uniprot IDs		B2R4P9 P84243	Q12830
PDB IDs		2L43 3ASK 3ASL 3AV2 3JVK 3MUK 3MUL 3QL9 3QLA 3QLC 3WTP 4GNE 4GNF 4GNG 4GU0 4GUR 4GUS 4GY5 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 4L58 4N4I 4O62 4QQ4 4TMP 4U7T 4W5A 5B32 5B33 5BNV 5BNX 5DWQ 5DX0 5JA4 5JJY 5JLB 5KDM 5X7X 6A5L 6A5O 6A5P 6A5R 6A5T 6A5U 6HGT 6INQ 6IR9 6J4W 6J4X 6J4Y 6J4Z 6J50 6J51 6J9J 6PZV 6QXZ 6R0C 6RNY 6U04 7A08	2F6J 2F6N 2FSA 2FUI 2FUU 2RI7 3QZS 3QZT 3QZV 3UV2 5H6Y 5R4G 5R4H 5R4I 5R4J 5R4K 5R4L 5R4M 5R4N 5R4O 6AZE 7K6R 7K6S 7KDW 7KDZ
Enriched GO Terms of Interacting Partners?
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