GPSM2 and ARHGEF40

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GPSM2	ARHGEF40
Description		G protein signaling modulator 2	Rho guanine nucleotide exchange factor 40
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cell Cortex Lateral Plasma Membrane Protein-containing Complex Mitotic Spindle Pole Lateral Cell Cortex Cell Cortex Region	Cytosol Plasma Membrane
	Molecular Function	Nucleotide Binding G-protein Alpha-subunit Binding GDP-dissociation Inhibitor Activity Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Identical Protein Binding Protein Self-association Dynein Complex Binding	Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Spindle Organization G Protein-coupled Receptor Signaling Pathway Ran Protein Signal Transduction Regulation Of Catalytic Activity Cell Division Maintenance Of Centrosome Location Regulation Of Mitotic Spindle Organization Positive Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Spindle Assembly	Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		G alpha (i) signalling events	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOC GTPase cycle
Drugs
Diseases
GWAS		Fat distribution (HIV) ( 21897333)	Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Neuroblastoma (pediatric) ( 32599975) Pediatric nonalcoholic steatohepatitis ( 28918882) Plateletcrit ( 32888494) PR interval ( 32439900) Red blood cell count ( 32888494) Resting heart rate ( 27798624)
Interacting Genes		17 interacting genes: AGR2 ARHGEF40 CLCC1 DLG4 FXR1 FXR2 GAS2L1 GLIS2 GNAI1 GNAI2 GNAI3 GNAO1 HRAS INSC LRRC8E NUMA1 WHRN	7 interacting genes: APP CBY2 GPSM2 MAPT MYCBP STC2 TAC1
Entrez ID		29899	55701
HPRD ID		06609	13335
Ensembl ID		ENSG00000121957	ENSG00000165801
Uniprot IDs		A0A024R0F8 B4DIF1 P81274	Q8TER5
PDB IDs		3SF4 4WND 4WNE 4WNF 4WNG 5A6C 6HC2
Enriched GO Terms of Interacting Partners?
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