GRM3 and TAMALIN

Number of citations of the paper that reports this interaction (PubMedID 11850456)
67

Data Source:
HPRD (two hybrid)

		GRM3	TAMALIN
Description		glutamate metabotropic receptor 3	trafficking regulator and scaffold protein tamalin
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Axon Dendritic Spine Astrocyte Projection Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Plasma Membrane Postsynaptic Density Postsynaptic Membrane Perinuclear Region Of Cytoplasm Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Glutamate Receptor Activity Scaffold Protein Binding	PDZ Domain Binding Small GTPase Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Gene Expression Regulation Of Synaptic Transmission, Glutamatergic	Signal Transduction Protein Localization Regulation Of Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		LY2140023
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 27611488) Autism spectrum disorder or schizophrenia ( 28540026) Brachial circumference ( 22479309) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Feeling worry ( 29500382) Hand grip strength (Mahalanobis distance) ( 32235003) LDL cholesterol levels in HIV infection ( 33109212) Neurociticism ( 29500382) Neuroticism ( 29255261) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656 30285260) Seborrheic dermatitis ( 29203360) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		15 interacting genes: APOA5 BET1 CA3 CALM1 CDK2AP1 CYP51A1 GRIP1 OCM2 PICK1 PPM1A SDCBP SLC22A1 TAMALIN ZNF219 ZNF804B	13 interacting genes: ACE2 CYTH3 DLG4 DOCK1 FYN GABBR2 GRM1 GRM2 GRM3 GRM5 KRT72 RPS6KA1 SRC
Entrez ID		2913	160622
HPRD ID		03070	17077
Ensembl ID		ENSG00000198822	ENSG00000161835
Uniprot IDs		A4D1D0 Q14832	Q7Z6J2
PDB IDs		1S8M 3SM9 4XAR 5CNK 5CNM 6B7H	2PNT
Enriched GO Terms of Interacting Partners?
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