GRM3 and CYP51A1

		GRM3	CYP51A1
Description		glutamate metabotropic receptor 3	cytochrome P450 family 51 subfamily A member 1
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Axon Dendritic Spine Astrocyte Projection Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Glutamate Receptor Activity Scaffold Protein Binding	Monooxygenase Activity Iron Ion Binding Sterol 14-demethylase Activity Oxidoreductase Activity Heme Binding
	Biological Process	Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Gene Expression Regulation Of Synaptic Transmission, Glutamatergic	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Sterol Metabolic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein Secretion Demethylation Negative Regulation Of Amyloid-beta Clearance
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)	Cholesterol biosynthesis Endogenous sterols Activation of gene expression by SREBF (SREBP) EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs		LY2140023	Tioconazole Itraconazole Levoketoconazole (S)-econazole
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 27611488) Autism spectrum disorder or schizophrenia ( 28540026) Brachial circumference ( 22479309) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Feeling worry ( 29500382) Hand grip strength (Mahalanobis distance) ( 32235003) LDL cholesterol levels in HIV infection ( 33109212) Neurociticism ( 29500382) Neuroticism ( 29255261) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656 30285260) Seborrheic dermatitis ( 29203360) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lifespan ( 25918517) Pulse pressure ( 30578418)
Interacting Genes		15 interacting genes: APOA5 BET1 CA3 CALM1 CDK2AP1 CYP51A1 GRIP1 OCM2 PICK1 PPM1A SDCBP SLC22A1 TAMALIN ZNF219 ZNF804B	4 interacting genes: GRM3 SHANK3 STT3B ZNF420
Entrez ID		2913	1595
HPRD ID		03070	03381
Ensembl ID		ENSG00000198822	ENSG00000001630
Uniprot IDs		A4D1D0 Q14832	A0A0C4DFL7 Q16850
PDB IDs		1S8M 3SM9 4XAR 5CNK 5CNM 6B7H	3JUS 3JUV 3LD6 4UHI 4UHL 6Q2T 6UEZ
Enriched GO Terms of Interacting Partners?
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