GRM2 and CLDN2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GRM2	CLDN2
Description		glutamate metabotropic receptor 2	claudin 2
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Axon Dendrite Presynaptic Membrane Astrocyte Projection Integral Component Of Postsynaptic Membrane	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Integral Component Of Membrane
	Molecular Function	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Protein Binding Glutamate Receptor Activity Scaffold Protein Binding	Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Gene Expression Glutamate Secretion Regulation Of Glutamate Secretion Regulation Of Dopamine Secretion Behavioral Response To Nicotine Response To Cocaine Regulation Of Protein Kinase B Signaling Regulation Of Synaptic Transmission, Glutamatergic Glutamate Homeostasis Regulation Of Response To Drug	Cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Bicellular Tight Junction Assembly
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)	Tight junction interactions
Drugs		LY2140023
Diseases
GWAS			Alcoholic chronic pancreatitis ( 28754779) Pancreatitis ( 23143602)
Interacting Genes		29 interacting genes: ACBD5 AQP6 BIK CCDC107 CLDN2 CLDN9 CPLX4 CYB5R3 GNA15 GNAQ GRIP1 LMNA MFSD14B MGST3 MMGT1 NAALADL2 PDZK1IP1 RGS12 SAR1A SDCBP SLC30A8 SLC38A1 STOM TAMALIN TMEM130 TMEM237 TMEM248 TSPAN18 UBQLN1	29 interacting genes: ADAM33 BTN3A2 CLEC2D CSGALNACT2 CXCL9 CYSRT1 EMP3 FAM209A GRM2 IGFBP5 IL27RA KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP4-12 LAT LNX1 LPAR3 MTDH NOTCH2NLA PIAS2 PLP1 TEX264 TJP1 TJP2 TMEM218 UBE2I WNK4
Entrez ID		2912	9075
HPRD ID		04977	06471
Ensembl ID		ENSG00000164082	ENSG00000165376
Uniprot IDs		Q14416	P57739
PDB IDs		4XAQ 4XAS 5CNI 5CNJ 5KZN 5KZQ	4YYX
Enriched GO Terms of Interacting Partners?
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