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GRIN1 and HNRNPU
Number of citations of the paper that reports this interaction (PubMedID
10862698
)
367
Data Source:
HPRD
(in vivo)
GRIN1
HNRNPU
Description
glutamate ionotropic receptor NMDA type subunit 1
heterogeneous nuclear ribonucleoprotein U
Image
GO Annotations
Cellular Component
Cytoplasm
Endoplasmic Reticulum Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
Synaptic Vesicle
Cell Surface
Postsynaptic Density
NMDA Selective Glutamate Receptor Complex
Dendrite
Neuron Projection
Synaptic Cleft
Terminal Bouton
Dendritic Spine
Synapse
Postsynaptic Membrane
Excitatory Synapse
Synaptic Membrane
Nuclear Chromosome
Kinetochore
Spindle Pole
Nucleus
Nucleoplasm
Telomerase Holoenzyme Complex
Centrosome
Cell Surface
Membrane
Nuclear Matrix
Nuclear Speck
Midbody
Dendrite Cytoplasm
Protein-containing Complex
Cytoplasmic Ribonucleoprotein Granule
CRD-mediated MRNA Stability Complex
Catalytic Step 2 Spliceosome
Mitotic Spindle
Inactive Sex Chromosome
Mitotic Spindle Midzone
Mitotic Spindle Microtubule
Ribonucleoprotein Complex
Molecular Function
Amyloid-beta Binding
NMDA Glutamate Receptor Activity
Calcium Channel Activity
Calcium Ion Binding
Protein Binding
Calmodulin Binding
Ligand-gated Ion Channel Activity
Glycine Binding
Glutamate Binding
Glutamate-gated Calcium Ion Channel Activity
Signaling Receptor Activity
Neurotransmitter Binding
Protein-containing Complex Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Complex Binding
TFIIH-class Transcription Factor Complex Binding
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Transcription Corepressor Activity
RNA Binding
Double-stranded RNA Binding
Single-stranded RNA Binding
MRNA 3'-UTR Binding
Actin Binding
Protein Binding
ATP Binding
Poly(A) Binding
SnRNA Binding
Poly(C) RNA Binding
Chromatin DNA Binding
Poly(G) Binding
Pre-mRNA Binding
Identical Protein Binding
Ribonucleoprotein Complex Binding
Protein-containing Complex Binding
Telomerase RNA Binding
RNA Polymerase II C-terminal Domain Binding
Sequence-specific Double-stranded DNA Binding
Promoter-specific Chromatin Binding
Biological Process
Cation Transport
Chemical Synaptic Transmission
Brain Development
Visual Learning
Positive Regulation Of Calcium Ion Transport Into Cytosol
Propylene Metabolic Process
Calcium-mediated Signaling
Ionotropic Glutamate Receptor Signaling Pathway
Regulation Of Membrane Potential
Response To Ethanol
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Synaptic Plasticity
Protein Heterotetramerization
Calcium Ion Homeostasis
Excitatory Postsynaptic Potential
Calcium Ion Transmembrane Import Into Cytosol
Excitatory Chemical Synaptic Transmission
Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Cellular Response To Amyloid-beta
Response To Glycine
Positive Regulation Of Excitatory Postsynaptic Potential
Positive Regulation Of Cysteine-type Endopeptidase Activity
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Alternative MRNA Splicing, Via Spliceosome
MRNA Splicing, Via Spliceosome
Osteoblast Differentiation
Chromatin Organization
RNA Processing
Cell Cycle
Regulation Of Mitotic Cell Cycle
Dosage Compensation By Inactivation Of X Chromosome
Negative Regulation Of Telomere Maintenance Via Telomerase
Circadian Regulation Of Gene Expression
Negative Regulation Of Kinase Activity
Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Positive Regulation Of Transcription By RNA Polymerase II
MRNA Stabilization
Cell Division
Maintenance Of Protein Location In Nucleus
Cardiac Muscle Cell Development
CRD-mediated MRNA Stabilization
Cellular Response To Glucocorticoid Stimulus
Positive Regulation Of Brown Fat Cell Differentiation
Dendritic Transport Of Messenger Ribonucleoprotein Complex
Regulation Of Mitotic Spindle Assembly
Regulation Of Chromatin Organization
Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore
Protein Localization To Spindle Microtubule
RNA Localization To Chromatin
Cellular Response To Leukemia Inhibitory Factor
Adaptive Thermogenesis
Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Positive Regulation Of Stem Cell Proliferation
Negative Regulation Of Stem Cell Differentiation
Pathways
EPHB-mediated forward signaling
EPHB-mediated forward signaling
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade
Neurexins and neuroligins
Synaptic adhesion-like molecules
Assembly and cell surface presentation of NMDA receptors
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
mRNA Splicing - Major Pathway
Processing of Capped Intron-Containing Pre-mRNA
Drugs
Glutamic acid
Tramadol
Enflurane
Atomoxetine
Pentobarbital
Methadone
Secobarbital
Meperidine
Acamprosate
Donepezil
Guaifenesin
Memantine
Memantine
Orphenadrine
Phenobarbital
Aripiprazole
Prasterone
5,7-Dichlorokynurenic acid
D-Serine
Cycloleucine
Milnacipran
CNS-5161
Acetylcysteine
Ketobemidone
Gavestinel
Agmatine
Ifenprodil
Magnesium acetate tetrahydrate
Magnesium carbonate
Esketamine
Fluciclovine (18F)
Diseases
GWAS
Post-traumatic stress disorder (asjusted for relatedness) (
23726511
)
Interacting Genes
58 interacting genes:
ACTN2
AKAP9
APP
BDKRB1
CALM1
CAMK2A
CAMK2G
CANX
CDH2
CIT
CLTC
CTNNB1
DLG1
DLG2
DLG3
DLG4
DLGAP4
DNM1
DRD1
DUSP4
EPHB2
EPHB4
FUS
FYN
GRIN2A
GRIN2B
GRIN2D
GRIN3A
HNRNPU
HRAS
HSPA1A
INA
LNX1
LRP8
MAP2
MAP2K2
MYH9
NANOS1
NEFL
NF1
PLAT
PLCG1
PPP2R1A
PPP2R2A
PRKCA
PRKCB
PRKCE
PRKCG
PTAFR
RAP2A
RPS6KA3
SP1
SP3
SPTAN1
SYNGAP1
TJP1
TRAF3
TUBA4B
39 interacting genes:
ACTB
BTRC
CASP3
CD5
CDKN2A
CR2
DUX4
ELL
EP300
ERG
GRIN1
GRIN2D
GTF2H1
HMGB1
HNRNPH3
HSPB1
IL7R
KAT2B
NDN
NDRG1
NEDD4
NR3C1
PIN1
POLR2A
POU3F4
PRMT1
PRPF40A
PTPN11
RBPMS2
SMN1
SREK1
STAU1
SUMO2
SYK
TCERG1
UBE2I
WBP4
YAP1
ZNF689
Entrez ID
2902
3192
HPRD ID
15926
04185
Ensembl ID
ENSG00000176884
ENSG00000153187
Uniprot IDs
Q05586
Q59GW0
Q5VSF9
Q00839
Q96BA7
PDB IDs
2HQW
2NR1
3BYA
5H8F
5H8H
5H8N
5H8Q
5I2K
5I2N
5KCJ
5KDT
5TP9
5TPA
6IRA
6IRF
6IRG
6IRH
1ZRJ
Enriched GO Terms of Interacting Partners
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