HNRNPU and ELL

Number of citations of the paper that reports this interaction (PubMedID 10490622)
19

Data Source:
HPRD (in vivo)

		HNRNPU	ELL
Description		heterogeneous nuclear ribonucleoprotein U	elongation factor for RNA polymerase II
Image
GO Annotations	Cellular Component	Nuclear Chromosome Kinetochore Spindle Pole Nucleus Nucleoplasm Telomerase Holoenzyme Complex Centrosome Cell Surface Membrane Nuclear Matrix Nuclear Speck Midbody Dendrite Cytoplasm Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule CRD-mediated MRNA Stability Complex Catalytic Step 2 Spliceosome Mitotic Spindle Inactive Sex Chromosome Mitotic Spindle Midzone Mitotic Spindle Microtubule Ribonucleoprotein Complex	Nucleoplasm Cytosol Transcription Elongation Factor Complex Cajal Body Nuclear Body Nuclear Speck Transcriptionally Active Chromatin Histone Locus Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding TFIIH-class Transcription Factor Complex Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Corepressor Activity RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding MRNA 3'-UTR Binding Actin Binding Protein Binding ATP Binding Poly(A) Binding SnRNA Binding Poly(C) RNA Binding Chromatin DNA Binding Poly(G) Binding Pre-mRNA Binding Identical Protein Binding Ribonucleoprotein Complex Binding Protein-containing Complex Binding Telomerase RNA Binding RNA Polymerase II C-terminal Domain Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	Protein Binding Phosphatase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Osteoblast Differentiation Chromatin Organization RNA Processing Cell Cycle Regulation Of Mitotic Cell Cycle Dosage Compensation By Inactivation Of X Chromosome Negative Regulation Of Telomere Maintenance Via Telomerase Circadian Regulation Of Gene Expression Negative Regulation Of Kinase Activity Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Transcription By RNA Polymerase II MRNA Stabilization Cell Division Maintenance Of Protein Location In Nucleus Cardiac Muscle Cell Development CRD-mediated MRNA Stabilization Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Brown Fat Cell Differentiation Dendritic Transport Of Messenger Ribonucleoprotein Complex Regulation Of Mitotic Spindle Assembly Regulation Of Chromatin Organization Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein Localization To Spindle Microtubule RNA Localization To Chromatin Cellular Response To Leukemia Inhibitory Factor Adaptive Thermogenesis Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Stem Cell Differentiation	In Utero Embryonic Development Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter SnRNA Transcription By RNA Polymerase II SnRNA Transcription By RNA Polymerase III Positive Regulation Of Transcription By RNA Polymerase III
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events Transcription-Coupled Nucleotide Excision Repair (TC-NER) TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS			Alanine aminotransferase levels ( 34315874) Alzheimer's disease (late onset) ( 30820047) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 34315874) Body shape index ( 34021172) Breast cancer ( 29059683 23535729) Coronary artery disease ( 29212778) HDL cholesterol levels ( 32203549) Iron status biomarkers (ferritin levels) ( 33536631) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Monocyte count ( 32888494) Pulse pressure ( 30224653) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist-hip index ( 34021172)
Interacting Genes		39 interacting genes: ACTB BTRC CASP3 CD5 CDKN2A CR2 DUX4 ELL EP300 ERG GRIN1 GRIN2D GTF2H1 HMGB1 HNRNPH3 HSPB1 IL7R KAT2B NDN NDRG1 NEDD4 NR3C1 PIN1 POLR2A POU3F4 PRMT1 PRPF40A PTPN11 RBPMS2 SMN1 SREK1 STAU1 SUMO2 SYK TCERG1 UBE2I WBP4 YAP1 ZNF689	14 interacting genes: CCAR2 EAF1 EAF2 EP300 HDAC3 HNRNPU MCM2 POLR2A PRKACA SNF8 TFPT TP53 UBC ZHX1
Entrez ID		3192	8178
HPRD ID		04185	02615
Ensembl ID		ENSG00000153187	ENSG00000105656
Uniprot IDs		Q00839 Q96BA7	P55199 U3KQ90
PDB IDs		1ZRJ	2DOA
Enriched GO Terms of Interacting Partners?
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