DBNL and MAP4K1

Number of citations of the paper that reports this interaction (PubMedID 10567356)
18

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		DBNL	MAP4K1
Description		drebrin like	mitogen-activated protein kinase kinase kinase kinase 1
Image
GO Annotations	Cellular Component	Golgi Membrane Ruffle Podosome Extracellular Region Cytoplasm Early Endosome Cytosol Actin Filament Plasma Membrane Cell Cortex Postsynaptic Density Lamellipodium Dendrite Site Of Polarized Growth Clathrin-coated Vesicle Membrane Cortical Actin Cytoskeleton Secretory Granule Lumen Perikaryon Postsynaptic Membrane Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Membrane
	Molecular Function	Actin Binding Protein Binding Protein C-terminus Binding Enzyme Activator Activity Protein Domain Specific Binding Cadherin Binding Actin Filament Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Protein Serine Kinase Activity
	Biological Process	Adaptive Immune Response Receptor-mediated Endocytosis Synapse Assembly Rac Protein Signal Transduction Regulation Of Actin Filament Polymerization Positive Regulation Of Axon Extension Neuron Projection Morphogenesis Regulation Of Catalytic Activity Positive Regulation Of Dendritic Spine Morphogenesis Podosome Assembly Ruffle Assembly Postsynaptic Actin Cytoskeleton Organization	Protein Phosphorylation JNK Cascade Cell Population Proliferation Peptidyl-serine Phosphorylation Protein Autophosphorylation Cellular Response To Phorbol 13-acetate 12-myristate
Pathways		Caspase-mediated cleavage of cytoskeletal proteins Neurexins and neuroligins Neutrophil degranulation
Drugs			Fostamatinib
Diseases
GWAS		Blood protein levels ( 30072576)	Diisocyanate-induced asthma ( 25918132)
Interacting Genes		14 interacting genes: ACD CASP3 HOMER1 MAP4K1 NEURL4 OGT POT1 SH2D4A SH3BP2 SHANK3 SYK TERF1 TERF2IP ZAP70	22 interacting genes: ABL1 BLNK CARD11 CASP3 CRK CRKL DAPP1 DBNL EGFR GRAP2 GRB2 H2AC4 HCLS1 LAT LCP2 LYN MAP3K11 MAP3K7 NCK1 SHC1 SYK TMEM101
Entrez ID		28988	11184
HPRD ID		06588	03583
Ensembl ID		ENSG00000136279	ENSG00000104814
Uniprot IDs		B4DUF9 Q9UJU6	Q92918
PDB IDs		1X67	6CQD 6CQE 6CQF 6NFY 6NFZ 6NG0 7KAC
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?