MAP4K1 and HCLS1

Number of citations of the paper that reports this interaction (PubMedID 10233887)
8

Data Source:
HPRD (in vivo)

		MAP4K1	HCLS1
Description		mitogen-activated protein kinase kinase kinase kinase 1	hematopoietic cell-specific Lyn substrate 1
Image			No pdb structure
GO Annotations	Cellular Component	Membrane	Nucleus Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Actin Filament Plasma Membrane Site Of Polarized Growth Cortical Actin Cytoskeleton
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Protein Serine Kinase Activity	Protein Binding SH3 Domain Binding Protein Kinase Binding Actin Filament Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Protein Phosphorylation JNK Cascade Cell Population Proliferation Peptidyl-serine Phosphorylation Protein Autophosphorylation Cellular Response To Phorbol 13-acetate 12-myristate	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Population Proliferation Response To Hormone Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Actin Filament Polymerization Erythrocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Cellular Response To Cytokine Stimulus Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132)
Interacting Genes		22 interacting genes: ABL1 BLNK CARD11 CASP3 CRK CRKL DAPP1 DBNL EGFR GRAP2 GRB2 H2AC4 HCLS1 LAT LCP2 LYN MAP3K11 MAP3K7 NCK1 SHC1 SYK TMEM101	24 interacting genes: ACTA1 ACTR2 ACTR3 BLZF1 CASP3 CD79A CSNK2A1 FGR GRB2 HAX1 HS1BP3 IKBKG LYN LZTR1 MAP4K1 QKI SH2D4A SH3BP2 SSBP3 SYK TERF1 TRIM29 WAS ZBTB25
Entrez ID		11184	3059
HPRD ID		03583	03199
Ensembl ID		ENSG00000104814	ENSG00000180353
Uniprot IDs		Q92918	P14317
PDB IDs		6CQD 6CQE 6CQF 6NFY 6NFZ 6NG0 7KAC
Enriched GO Terms of Interacting Partners?
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