DOK7 and MUSK

Number of citations of the paper that reports this interaction (PubMedID 16794080)
139

Data Source:
HPRD (in vivo)

		DOK7	MUSK
Description		docking protein 7	muscle associated receptor tyrosine kinase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Plasma Membrane Synapse	Integral Component Of Plasma Membrane Neuromuscular Junction Receptor Complex Postsynaptic Membrane
	Molecular Function	Protein Binding Lipid Binding Protein Kinase Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Tyrosine Kinase Collagen Receptor Activity Metal Ion Binding
	Biological Process	Neuromuscular Junction Development Positive Regulation Of Protein Tyrosine Kinase Activity	Positive Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Neuromuscular Junction Development Memory Regulation Of Synaptic Assembly At Neuromuscular Junction Positive Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Kinase Activity Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Protein Autophosphorylation Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Protein Geranylgeranylation
Pathways			ECM proteoglycans
Drugs			Fostamatinib
Diseases
GWAS		Calcium levels ( 29403010) Coronary artery disease ( 33020668) Fibrinogen levels ( 28107422) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)	Body mass index ( 28552196) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Orofacial cleft x maternal periconceptional smoking interaction (1df) ( 33937227) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Pulmonary function decline ( 22424883) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)
Interacting Genes		8 interacting genes: APPL1 BCAR1 CRK EFEMP2 EFHC1 MPZL1 MUSK YPEL3	7 interacting genes: COLQ DOK7 ERBIN ILKAP RAPSN STYX SYNE1
Entrez ID		285489	4593
HPRD ID		08744	03190
Ensembl ID		ENSG00000175920	ENSG00000030304
Uniprot IDs		A0A1W2PRA3 Q18PE1 Q8N1M3	A0A087WSY1 O15146
PDB IDs
Enriched GO Terms of Interacting Partners?
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