NKIRAS1 and XRCC2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		NKIRAS1	XRCC2
Description		NFKB inhibitor interacting Ras like 1	X-ray repair cross complementing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Cytosol	Nucleoplasm Replication Fork Cytoplasm Centrosome Rad51B-Rad51C-Rad51D-XRCC2 Complex Intracellular Membrane-bounded Organelle
	Molecular Function	GTPase Activity GTP Binding	Four-way Junction DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA
	Biological Process	I-kappaB Kinase/NF-kappaB Signaling	Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Somitogenesis DNA Repair Centrosome Cycle Response To X-ray Response To Gamma Radiation Multicellular Organism Growth Strand Invasion Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neurogenesis Meiotic Cell Cycle Regulation Of Fibroblast Apoptotic Process
Pathways		RIP-mediated NFkB activation via ZBP1 TAK1 activates NFkB by phosphorylation and activation of IKKs complex TRAF6 mediated NF-kB activation	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Intake of total sugars ( 31005972) Intelligence (MTAG) ( 29326435)	Diabetic kidney disease ( 26305897) Mean platelet volume ( 32888494 27863252) Palmitic acid (16:0) levels ( 23362303)
Interacting Genes		8 interacting genes: ACVR1 APP BMPR1B NFKBIA NFKBIB SMURF2 TGFBR1 XRCC2	5 interacting genes: MEOX2 NKIRAS1 RAD51 RAD51D WFDC1
Entrez ID		28512	7516
HPRD ID		06841	02656
Ensembl ID		ENSG00000197885	ENSG00000196584
Uniprot IDs		Q9NYS0	A0A384MEK2 O43543
PDB IDs
Enriched GO Terms of Interacting Partners?
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