ANGPT1 and ANGPT2

Number of citations of the paper that reports this interaction (PubMedID 9204896)
782

Data Source:
HPRD (in vivo, in vitro)

		ANGPT1	ANGPT2
Description		angiopoietin 1	angiopoietin 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Microvillus Membrane Raft Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Plasma Membrane Cell Projection Collagen-containing Extracellular Matrix
	Molecular Function	Signaling Receptor Binding Receptor Tyrosine Kinase Binding	Signaling Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding Metal Ion Binding
	Biological Process	Angiogenesis In Utero Embryonic Development Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Positive Regulation Of Receptor Internalization Negative Regulation Of Cytokine Production Involved In Immune Response Negative Regulation Of Cell Adhesion Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Skeletal Muscle Satellite Cell Proliferation Hemopoiesis Cell Differentiation Heparin Biosynthetic Process Positive Regulation Of Protein Ubiquitination Cell-substrate Adhesion Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Peptidyl-serine Phosphorylation Protein Localization To Cell Surface Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Negative Regulation Of Vascular Permeability Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Binding Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Adhesion Tie Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Glomerulus Vasculature Development Positive Regulation Of Blood-brain Barrier Permeability Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway	Angiogenesis Response To Hypoxia Signal Transduction Germ Cell Development Response To Radiation Response To Mechanical Stimulus Response To Glucose Gene Expression Negative Regulation Of Cell-substrate Adhesion Response To Organic Cyclic Compound Response To Activity Negative Regulation Of Angiogenesis Animal Organ Regeneration Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Tie Signaling Pathway Negative Regulation Of Positive Chemotaxis Maternal Process Involved In Female Pregnancy Cellular Response To Growth Factor Stimulus Glomerulus Vasculature Development
Pathways		Tie2 Signaling Tie2 Signaling RAF/MAP kinase cascade	Tie2 Signaling
Drugs			Faricimab
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Corneal astigmatism ( 29422769) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Face memory ( 31596458) Fractional exhaled nitric oxide (childhood) ( 24315451) Glaucoma ( 31959993 30054594) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (primary open-angle) ( 33627673 29891935) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Intraocular pressure ( 29617998 29785010 31959993 30054594 29235454) Male-pattern baldness ( 28196072) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (antiglaucoma preparations and miotics) ( 31015401) Periodontitis (stage III/IV grade C) ( 33745150) Periventricular white matter hyperintensities ( 32517579) Platelet distribution width ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Reticulocyte fraction of red cells ( 32888494)	Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 30072576) Dental caries (decayed and filled deciduous teeth) ( 31533690) Intraocular pressure ( 29617998 29785010 30054594) Metabolite levels ( 23823483) Response to cytidine analogues (gemcitabine) ( 24483146)
Interacting Genes		4 interacting genes: ANGPT2 ITGA5 TEK TIE1	6 interacting genes: ANGPT1 ANXA7 CDKN1A CSNK2B ITGA5 TEK
Entrez ID		284	285
HPRD ID		03392	03563
Ensembl ID		ENSG00000154188	ENSG00000091879
Uniprot IDs		B4DTQ9 Q15389	O15123
PDB IDs		4EPU 4JYO 4K0V	1Z3S 1Z3U 2GY7 4JZC 4ZFG
Enriched GO Terms of Interacting Partners?
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