SLCO1B3 and CCKBR

Number of citations of the paper that reports this interaction (PubMedID 10320330)
6

Data Source:
BioGRID (pull down)

		SLCO1B3	CCKBR
Description		solute carrier organic anion transporter family member 1B3	cholecystokinin B receptor
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Organic Anion Transmembrane Transporter Activity Bile Acid Transmembrane Transporter Activity Sodium-independent Organic Anion Transmembrane Transporter Activity	G Protein-coupled Receptor Activity Cholecystokinin Receptor Activity Protein Binding Gastrin Receptor Activity Peptide Hormone Binding Type B Gastrin/cholecystokinin Receptor Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Organic Anion Transport Bile Acid And Bile Salt Transport Heme Catabolic Process Sodium-independent Organic Anion Transport Transmembrane Transport	Gastric Acid Secretion Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Population Proliferation Cholecystokinin Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase Activity PH Reduction Digestive Tract Development Gland Development
Pathways		Recycling of bile acids and salts Heme degradation Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) Transport of organic anions	Peptide ligand-binding receptors G alpha (q) signalling events Gastrin-CREB signalling pathway via PKC and MAPK
Drugs		Clarithromycin Gemfibrozil Ginsenoside Rb1 Ginsenoside Rg1	Pentagastrin Cholecystokinin
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 34315874) Bilirubin levels ( 31801373 19419973 31319653 23371916 20639394) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Height ( 18391951) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Parkinson's disease progression (cognitive) ( 33111402) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Total bilirubin levels ( 29403010)	Diastolic blood pressure ( 30224653) Early spontaneous preterm birth ( 31194736) Gastroesophageal reflux disease ( 31527586) Malaria ( 31844061) Rheumatic heart disease ( 34106200)
Interacting Genes		1 interacting genes: CCKBR	10 interacting genes: ADRB2 ATP13A2 CCK CCKAR CCR4 DRD2 NTM PPP1R9B PTPN11 SLCO1B3
Entrez ID		28234	887
HPRD ID		12021	00323
Ensembl ID		ENSG00000111700	ENSG00000110148
Uniprot IDs		B3KP78 Q9NPD5	E9PIC8 P32239
PDB IDs			1L4T
Enriched GO Terms of Interacting Partners?
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