SLCO3A1 and ACAN

		SLCO3A1	ACAN
Description		solute carrier organic anion transporter family member 3A1	aggrecan
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Golgi Lumen Extracellular Matrix Lysosomal Lumen Collagen-containing Extracellular Matrix
	Molecular Function	Sodium-independent Organic Anion Transmembrane Transporter Activity	Extracellular Matrix Structural Constituent Protein Binding Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Prostaglandin Transport Sodium-independent Organic Anion Transport Positive Regulation Of NF-kappaB Transcription Factor Activity Transmembrane Transport Transport Across Blood-brain Barrier	Skeletal System Development Proteolysis Cell Adhesion Central Nervous System Development
Pathways			Degradation of the extracellular matrix Degradation of the extracellular matrix Keratan sulfate biosynthesis Keratan sulfate degradation ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Drugs			Ilomastat
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) Adult body size ( 32376654) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Diastolic blood pressure ( 30224653) DNA methylation (variation) ( 23725790) Estimated glomerular filtration rate reduction (30%) ( 30955190) Gastroesophageal reflux disease ( 27485664) Inattentive symptoms ( 18821565) Neuritic plaque ( 25188341) Obesity-related traits ( 23251661) Orofacial cleft x maternal periconceptional alcohol use interaction (1df) ( 33937227) Post bronchodilator FEV1/FVC ratio ( 26634245) Primary sclerosing cholangitis ( 27992413) Refractive error ( 32231278) Response to iloperidone treatment (QT prolongation) ( 18521091) Smoking initiation ( 24665060)	Age-related hearing impairment ( 27764096) Appendicular lean mass ( 33097823) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Dupuytren's disease ( 28886342) Height ( 21998595 28552196 20881960 25282103 25133637 25429064 23563607 31562340 28270201 18391952 33713608) Hip circumference adjusted for BMI ( 34021172 25673412) Infant length ( 25281659) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500)
Interacting Genes		8 interacting genes: ACAN AQP6 C4orf3 GOLM1 PDZD3 SLC9A3R1 SLC9A3R2 TRARG1	23 interacting genes: ADAMTS1 ADAMTS4 ADAMTS5 BLM CTSB FBLN1 FBLN2 HAPLN1 IDH2 LUM MAN2A2 MMP1 MMP14 MMP19 MMP2 MMP20 MMP3 MMP8 PTPRF SLCO3A1 STARD5 TNFAIP6 TNR
Entrez ID		28232	176
HPRD ID		07502	01123
Ensembl ID		ENSG00000176463	ENSG00000157766
Uniprot IDs		Q9UIG8	A0A5K1VW97 P16112
PDB IDs			4MD4
Enriched GO Terms of Interacting Partners?
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