FBXL4 and RXRG

		FBXL4	RXRG
Description		F-box and leucine rich repeat protein 4	retinoid X receptor gamma
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Mitochondrial Intermembrane Space Cytosol Nuclear Speck SCF Ubiquitin Ligase Complex	Chromatin Nucleoplasm Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Retinoic Acid-responsive Element Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process	Regulation Of Transcription By RNA Polymerase II Cell Differentiation Response To Retinoic Acid Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Anatomical Structure Development
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Nuclear Receptor transcription pathway Signaling by Retinoic Acid
Drugs			Adapalene Bexarotene Rosiglitazone Acitretin Alitretinoin Tretinoin Etretinate Bezafibrate Phthalic Acid Doconexent
Diseases
GWAS		Chronotype ( 30696823) Depression ( 29700475) Experiencing mood swings ( 29500382) Feeling nervous ( 29500382) Major depressive disorder ( 27479909) Metabolite levels ( 23823483) Neurociticism ( 29500382) Regular attendance at a religious group ( 29970889)	AIDS ( 19754311) Bipolar disorder (age of onset <21) or attention deficit hyperactivity disorder ( 27890468) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Macular thickness ( 30535121) Menarche (age at onset) ( 27182965 21102462 29773799 25231870) Metabolite levels ( 23823483) Personality traits in bipolar disorder ( 21368711) Proportion of activated microglia (midfrontal cortex) ( 30679421) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		4 interacting genes: GP1BA MAP3K7 RXRG SKP1	33 interacting genes: CAMK2B CEBPZ CHGB CKMT1A CKMT1B CREBBP DCK FBXL4 HOXD4 ITGB3BP LRSAM1 MAP4 MPPED2 NCOA6 NCOR2 NR0B2 NR1H2 NR1H3 NR1H4 NR1I2 NR4A1 PICK1 PNO1 PPARA PPARD PPARG RARA RARB RARG SRF THRA THRB VDR
Entrez ID		26235	6258
HPRD ID		05738	01579
Ensembl ID		ENSG00000112234	ENSG00000143171
Uniprot IDs		Q9UKA2	A0A087WZ88 F1D8Q7 F1T097 P48443
PDB IDs			2GL8 7A79
Enriched GO Terms of Interacting Partners?
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