GNAO1 and PDE6H

Number of citations of the paper that reports this interaction (PubMedID 15215290)
25

Data Source:
HPRD (two hybrid)

		GNAO1	PDE6H
Description		G protein subunit alpha o1	phosphodiesterase 6H
Image			No pdb structure
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Dendrite Myelin Sheath Cell Body	Photoreceptor Outer Segment Membrane
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding GTPase Activating Protein Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	Enzyme Inhibitor Activity Protein Binding CGMP Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Muscle Contraction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Aging Locomotory Behavior Regulation Of Heart Contraction Response To Xenobiotic Stimulus Forebrain Development Neuron Projection Development Response To Cytokine Odontogenesis Of Dentin-containing Tooth Response To Hydrogen Peroxide Response To Morphine Positive Regulation Of GTPase Activity Negative Regulation Of Calcium Ion Transport	Visual Perception Negative Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Response To Stimulus
Pathways		Ca2+ pathway Ca2+ pathway
Drugs			Sildenafil Vardenafil
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Cardioembolic stroke (CCSp classification) ( 32047268) Chronotype ( 30696823) Daytime nap ( 33568662) Diastolic blood pressure ( 30578418) Dimensional psychopathology (Positive) ( 29496196) HDL cholesterol levels ( 32203549) Metabolite levels ( 23823483) Mitochondrial DNA copy number ( 30704525) Morning person ( 30696823) Pulse pressure ( 27841878) Sleep duration (short sleep) ( 30846698)
Interacting Genes		35 interacting genes: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CDK2 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR	6 interacting genes: AGTR1 APP COTL1 GNAO1 POU6F2 PRKAB2
Entrez ID		2775	5149
HPRD ID		00757	03116
Ensembl ID		ENSG00000087258	ENSG00000139053
Uniprot IDs		B3KP89 P09471 Q6AWC5 Q8N6I9	Q13956
PDB IDs		6FUF 6G79 6K41 6OIK 6WWZ
Enriched GO Terms of Interacting Partners?
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