PDE6H and COTL1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		PDE6H	COTL1
Description		phosphodiesterase 6H	coactosin like F-actin binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Membrane	Extracellular Region Nucleus Cytosol Actin Filament Plasma Membrane Cortical Actin Cytoskeleton Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Enzyme Inhibitor Activity Protein Binding CGMP Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Actin Binding Protein Binding Enzyme Binding Actin Filament Binding
	Biological Process	Visual Perception Negative Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Response To Stimulus	Biological_process Regulation Of Actin Filament Polymerization Defense Response To Fungus
Pathways			Neutrophil degranulation
Drugs		Sildenafil Vardenafil
Diseases
GWAS			Carotid intima media thickness x smoking interaction ( 32117412) Cleft lip with or without cleft palate (maternal periconceptional vitamin use interaction) ( 29535761) Cocaine dependence ( 31212010) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Heel bone mineral density ( 30598549) Macular thickness ( 30535121)
Interacting Genes		6 interacting genes: AGTR1 APP COTL1 GNAO1 POU6F2 PRKAB2	7 interacting genes: ACTA1 ACTB ACTG1 ALOX5 BBS5 PDE6H TERF2IP
Entrez ID		5149	23406
HPRD ID		03116	09482
Ensembl ID		ENSG00000139053	ENSG00000103187
Uniprot IDs		Q13956	A0A384MTY2 Q14019
PDB IDs			1T2L 1T3X 1T3Y 1TMW 1VFQ 1WNJ
Enriched GO Terms of Interacting Partners?
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