GLI1 and RAI1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid)

		GLI1	RAI1
Description		GLI family zinc finger 1	retinoic acid induced 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Axoneme Ciliary Tip Ciliary Base	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Microtubule Binding Metal Ion Binding	Protein Binding Metal Ion Binding
	Biological Process	Osteoblast Differentiation Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Spermatogenesis Ventral Midline Development Positive Regulation Of Cell Population Proliferation Regulation Of Smoothened Signaling Pathway Response To Wounding Epidermal Cell Differentiation Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Cerebellar Cortex Morphogenesis Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Pituitary Gland Development Lung Development Prostate Gland Development Regulation Of Osteoblast Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Morphogenesis Notochord Regression Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Liver Regeneration Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Hepatocyte Proliferation	Skeletal System Development Regulation Of Transcription By RNA Polymerase II Circadian Regulation Of Gene Expression Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Transcription, DNA-templated
Pathways		Degradation of GLI1 by the proteasome Degradation of GLI1 by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription	Circadian Clock Heme signaling
Drugs
Diseases
GWAS			Body mass index ( 28892062) Body shape index ( 34021172) Caffeine consumption from coffee ( 33287642) Coronary artery disease ( 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) General cognitive ability ( 29844566) Glycated hemoglobin levels ( 34059833) Hip circumference ( 25673412) Hip index ( 34021172) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte counts ( 27863252) Monocyte count ( 32888494) Offspring birth weight ( 31043758) Parkinson's disease ( 21738487) Schizophrenia ( 28991256 25056061 29483656) Type 2 diabetes ( 30054458 30297969) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		23 interacting genes: AQP1 CATSPER1 CCT2 CRYBA4 DYRK1A FEM1B GCC1 IKBKB PRKAA2 PRKACA PRMT1 PRMT5 RAI1 RUNX3 STK36 SUFU TAF9 TRIM42 USP48 WDR77 XBP1 ZIC1 ZIC2	22 interacting genes: CASP2 CCDC144A CDKN1A DDIT3 GADD45A GATA1 GLI1 GRAP GSK3B LZTR1 MAML3 MAPK8IP2 NCOR1 PEMT PIN1 RPS6KA5 TESC TET2 TOPBP1 TTR ULK2 ZNF496
Entrez ID		2735	10743
HPRD ID		01311	07406
Ensembl ID		ENSG00000111087	ENSG00000108557
Uniprot IDs		B4DNF7 P08151	Q7Z5J4
PDB IDs		2GLI 4BLB 4KMD 5OM0
Enriched GO Terms of Interacting Partners?
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