RAI1 and MAML3

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid)

		RAI1	MAML3
Description		retinoic acid induced 1	mastermind like transcriptional coactivator 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Protein Binding Metal Ion Binding	Transcription Coactivator Activity
	Biological Process	Skeletal System Development Regulation Of Transcription By RNA Polymerase II Circadian Regulation Of Gene Expression Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Transcription, DNA-templated	Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Circadian Clock Heme signaling	Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases
GWAS		Body mass index ( 28892062) Body shape index ( 34021172) Caffeine consumption from coffee ( 33287642) Coronary artery disease ( 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) General cognitive ability ( 29844566) Glycated hemoglobin levels ( 34059833) Hip circumference ( 25673412) Hip index ( 34021172) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte counts ( 27863252) Monocyte count ( 32888494) Offspring birth weight ( 31043758) Parkinson's disease ( 21738487) Schizophrenia ( 28991256 25056061 29483656) Type 2 diabetes ( 30054458 30297969) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Academic attainment (English) ( 33594131) Adult body size ( 32376654) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Borderline personality disorder ( 28632202) Chronic mucus hypersecretion ( 25234806) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Congenital heart malformation ( 23708190) Gastroesophageal reflux disease ( 31527586) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Malaria ( 31844061) Medication use (anti-inflammatory and antirheumatic products, non-steroids) ( 31015401) Multisite chronic pain ( 31194737) Smoking initiation ( 33082346) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Walking pace ( 33128006)
Interacting Genes		22 interacting genes: CASP2 CCDC144A CDKN1A DDIT3 GADD45A GATA1 GLI1 GRAP GSK3B LZTR1 MAML3 MAPK8IP2 NCOR1 PEMT PIN1 RPS6KA5 TESC TET2 TOPBP1 TTR ULK2 ZNF496	12 interacting genes: NFX1 NID2 NOTCH1 NOTCH2 NOTCH3 NOTCH4 RAI1 SCMH1 SUPT5H VPS26C ZBTB1 ZZZ3
Entrez ID		10743	55534
HPRD ID		07406	10066
Ensembl ID		ENSG00000108557	ENSG00000196782
Uniprot IDs		Q7Z5J4	Q96JK9 Q9NPV6
PDB IDs
Enriched GO Terms of Interacting Partners?
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