OPLAH and TPK1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

		OPLAH	TPK1
Description		5-oxoprolinase, ATP-hydrolysing	thiamin pyrophosphokinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Cytosol
	Molecular Function	Protein Binding ATP Binding 5-oxoprolinase (ATP-hydrolyzing) Activity Identical Protein Binding	Thiamine Diphosphokinase Activity Protein Binding ATP Binding Kinase Activity Thiamine Binding Identical Protein Binding
	Biological Process	Glutathione Metabolic Process	Thiamine Metabolic Process Thiamine Diphosphate Biosynthetic Process Phosphorylation
Pathways		Glutathione synthesis and recycling Defective OPLAH causes OPLAHD	Vitamin B1 (thiamin) metabolism
Drugs		Glutamic acid	Thiamine Pyrithiamine Pyrophosphate
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Blood metabolite levels ( 24816252) Mean spheric corpuscular volume ( 32888494) Metabolic traits ( 21886157) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 33031748 23093944)	Fruit consumption ( 32066663) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Iris color (b* coordinate) ( 30895295) Smoking status (heavy vs never) ( 26423011)
Interacting Genes		5 interacting genes: GK HOXA1 POU6F2 TPK1 ZNF451	1 interacting genes: OPLAH
Entrez ID		26873	27010
HPRD ID		14880	06967
Ensembl ID		ENSG00000178814	ENSG00000196511
Uniprot IDs		O14841	A0A090N8Y0 F5GZG6 Q9H3S4
PDB IDs			1OLY 3S4Y
Enriched GO Terms of Interacting Partners?
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