GDI1 and RAC2

Number of citations of the paper that reports this interaction (PubMedID 9490022)
17

Data Source:
HPRD (in vivo, in vitro)

		GDI1	RAC2
Description		GDP dissociation inhibitor 1	Rac family small GTPase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Axon Midbody Protein-containing Complex Neuronal Cell Body Myelin Sheath	Nuclear Envelope Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium Phagocytic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Extracellular Exosome
	Molecular Function	GDP-dissociation Inhibitor Activity Rab GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	GTPase Activity Protein Binding GTP Binding Protein Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Signal Transduction Protein Transport Vesicle-mediated Transport Rab Protein Signal Transduction Positive Regulation Of Axon Extension Negative Regulation Of Axonogenesis Regulation Of Catalytic Activity Response To Calcium Ion Negative Regulation Of Protein Targeting To Membrane	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction G Protein-coupled Receptor Signaling Pathway Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Lamellipodium Assembly Regulation Of Cell-substrate Adhesion Rac Protein Signal Transduction Cell Projection Assembly Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of T Cell Proliferation Regulation Of Mast Cell Degranulation Engulfment Of Apoptotic Cell Bone Resorption Regulation Of Catalytic Activity Regulation Of Respiratory Burst Regulation Of Mast Cell Chemotaxis Lymphocyte Aggregation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		RAB GEFs exchange GTP for GDP on RABs	GPVI-mediated activation cascade ROS and RNS production in phagocytes PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PCP/CE pathway RHO GTPases Activate NADPH Oxidases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RAC2 GTPase cycle
Drugs			Dextromethorphan
Diseases
GWAS			Celiac disease ( 31591516) Graves' disease ( 23612905) Longevity ( 20834067) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Type 1 diabetes ( 25751624)
Interacting Genes		18 interacting genes: CDC42 EPB41 GNL1 IRAK1 LNX1 OGT PACS1 PSEN1 RAB1B RAB27A RAB3B RAB6A RAB9A RABAC1 RAC2 RHOH TK1 UBQLN4	24 interacting genes: ACTB ADAM22 AFG3L2 AGAP2 ARFIP2 ARHGDIA ARHGDIB BRD2 CDC42 CHGB CHPF CUL1 DEF6 DOCK2 GDI1 HDAC7 ICMT NCF2 NOS2 NOXA1 PAK2 RTKN SMAD1 SMAD4
Entrez ID		2664	5880
HPRD ID		02114	03628
Ensembl ID		ENSG00000203879	ENSG00000128340
Uniprot IDs		A0A0S2Z3X8 P31150	A0A024R1P2 P15153 V9H0H7
PDB IDs			1DS6 2W2T 2W2V 2W2X
Enriched GO Terms of Interacting Partners?
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