GREM1 and BMP2

Number of citations of the paper that reports this interaction (PubMedID 15064755)
67

Data Source:
HPRD (in vitro)

		GREM1	BMP2
Description		gremlin 1, DAN family BMP antagonist	bone morphogenetic protein 2
Image
GO Annotations	Cellular Component	Extracellular Space Cell Surface Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Cell Surface Intracellular Membrane-bounded Organelle BMP Receptor Complex
	Molecular Function	Cytokine Activity Protein Binding Morphogen Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity BMP Binding Protein Homodimerization Activity Vascular Endothelial Growth Factor Receptor 2 Binding Receptor Ligand Activity	Signaling Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Phosphatase Activator Activity Co-receptor Binding Protein Serine/threonine Kinase Activator Activity SMAD Binding BMP Receptor Binding Transcription Regulator Activator Activity
	Biological Process	Cell Morphogenesis Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Receptor Internalization Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Apoptotic Process Signal Transduction Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Proximal/distal Pattern Formation Regulation Of Epithelial To Mesenchymal Transition Collagen Fibril Organization Negative Regulation Of Cell Growth Embryonic Limb Morphogenesis Negative Regulation Of Bone Mineralization Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Chondrocyte Differentiation Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Proliferation Sequestering Of BMP From Receptor Via BMP Binding Negative Regulation Of Apoptotic Process Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Bone Remodeling Determination Of Dorsal Identity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Focal Adhesion Assembly Positive Regulation Of Telomerase Activity Limb Development Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Ureteric Bud Formation Positive Regulation Of Protein Tyrosine Kinase Activity Signal Transduction By P53 Class Mediator Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Osteoclast Proliferation Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Bone Trabecula Formation Negative Regulation Of Bone Mineralization Involved In Bone Maturation Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Signaling Receptor Activity Positive Regulation Of Cardiac Muscle Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Osteoblast Differentiation Branching Involved In Ureteric Bud Morphogenesis Response To Hypoxia In Utero Embryonic Development Epithelial To Mesenchymal Transition Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Chondrocyte Differentiation BMP Signaling Pathway Involved In Heart Induction Aortic Valve Development Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Atrium Formation Endocardial Cushion Formation Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development Positive Regulation Of Extracellular Matrix Constituent Secretion Proteoglycan Metabolic Process Regulation Of Transcription, DNA-templated Protein Phosphorylation Inflammatory Response Notch Signaling Pathway Cell-cell Signaling Heart Development Negative Regulation Of Cell Population Proliferation Response To Bacterium Animal Organ Morphogenesis Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Steroid Biosynthetic Process Positive Regulation Of Phosphatase Activity Telencephalon Development Telencephalon Regionalization Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Destabilization Positive Regulation Of Protein Binding Negative Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Osteoblast Proliferation Cardiocyte Differentiation Embryonic Heart Tube Anterior/posterior Pattern Specification Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Bone Mineralization Involved In Bone Maturation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Fate Commitment Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Astrocyte Differentiation Mesenchymal Cell Differentiation Inner Ear Development Negative Regulation Of Calcium-independent Cell-cell Adhesion Positive Regulation Of DNA-binding Transcription Factor Activity Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Pericardium Development Corticotropin Hormone Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Cardiac Epithelial To Mesenchymal Transition Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Mesenchyme Development Positive Regulation Of Wnt Signaling Pathway By BMP Signaling Pathway Positive Regulation Of Cartilage Development BMP Signaling Pathway Involved In Heart Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Organic Cyclic Compound Cellular Response To BMP Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of P38MAPK Cascade Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Cardiac Jelly Development Atrioventricular Canal Morphogenesis Negative Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways			Signaling by BMP Molecules associated with elastic fibres Transcriptional regulation by RUNX2 Regulation of RUNX2 expression and activity
Drugs
Diseases
GWAS		Chin dimples ( 27182965) Colorectal cancer ( 25990418 21761138 26151821 24737748 23266556) Colorectal cancer or advanced adenoma ( 30510241) Haemorrhoidal disease ( 33888516) Hypospadias ( 25108383) Metabolite levels ( 23823483) Monobrow ( 27182965) Orofacial clefts ( 20023658)	Adult body size ( 32376654) Atrial fibrillation ( 29892015) Axial length ( 24144296) Body mass index ( 19079261 23669352 28892062 25673413) Body size at age 10 ( 32376654) Childhood ear infection ( 27182965) Colorectal cancer ( 25990418 30529582 26151821 29471430 24737748 31826910 23266556) Colorectal cancer or advanced adenoma ( 30510241) Copper levels ( 26025379) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) FEV1 ( 30804560) Heel bone mineral density ( 30598549 28869591) Height ( 20881960 25282103 25429064 23563607 31562340 18391951) Hip circumference adjusted for BMI ( 25673412) Lung function (FVC) ( 28166213 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Major depressive disorder (stressful life events interaction) ( 26845276) Mitochondrial heteroplasmy measurement ( 33731350) Nose morphology (partial least square model) ( 30174134) Obesity-related traits ( 23251661) Optic cup area ( 25631615 31798171 28073927) Peak expiratory flow ( 30804560) Pulse pressure ( 30224653) QRS complex (Cornell) ( 27659466) Refractive error ( 23396134 32231278) Retinal detachment or retinal break ( 31816047) Sagittal craniosynostosis ( 23160099) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels x loop diuretics use interaction ( 31806883) Vertical cup-disc ratio ( 31798171 25241763 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		4 interacting genes: BMP2 KRTAP12-2 MDFI YWHAH	21 interacting genes: ACTR2 ACVR1 ACVR2A ACVR2B ASCL1 BMPER BMPR1A BMPR1B BMPR2 CHRD CHRDL2 COL2A1 ENG GREM1 GREM2 MGP NOG RGMB SOSTDC1 TGFB1 TGFB2
Entrez ID		26585	650
HPRD ID		07048	00206
Ensembl ID		ENSG00000166923	ENSG00000125845
Uniprot IDs		A6XAA7 B3KTR9 O60565	C8C060 P12643
PDB IDs		5AEJ	1ES7 1REU 1REW 2GOO 2H62 2H64 2QJ9 2QJA 2QJB 3BK3 3BMP 4MID 4N1D 4UHY 4UHZ 4UI0 4UI1 4UI2 6OMN
Enriched GO Terms of Interacting Partners?
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