BMP2 and TGFB1

Number of citations of the paper that reports this interaction (PubMedID 11456401)
2

Data Source:
HPRD (in vivo)

		BMP2	TGFB1
Description		bone morphogenetic protein 2	transforming growth factor beta 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Intracellular Membrane-bounded Organelle BMP Receptor Complex	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Lumen Plasma Membrane Microvillus Cell Surface Extracellular Matrix Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Blood Microparticle
	Molecular Function	Signaling Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Phosphatase Activator Activity Co-receptor Binding Protein Serine/threonine Kinase Activator Activity SMAD Binding BMP Receptor Binding Transcription Regulator Activator Activity	Antigen Binding Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Enzyme Binding Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Osteoblast Differentiation Branching Involved In Ureteric Bud Morphogenesis Response To Hypoxia In Utero Embryonic Development Epithelial To Mesenchymal Transition Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Chondrocyte Differentiation BMP Signaling Pathway Involved In Heart Induction Aortic Valve Development Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Atrium Formation Endocardial Cushion Formation Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development Positive Regulation Of Extracellular Matrix Constituent Secretion Proteoglycan Metabolic Process Regulation Of Transcription, DNA-templated Protein Phosphorylation Inflammatory Response Notch Signaling Pathway Cell-cell Signaling Heart Development Negative Regulation Of Cell Population Proliferation Response To Bacterium Animal Organ Morphogenesis Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Steroid Biosynthetic Process Positive Regulation Of Phosphatase Activity Telencephalon Development Telencephalon Regionalization Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Destabilization Positive Regulation Of Protein Binding Negative Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Osteoblast Proliferation Cardiocyte Differentiation Embryonic Heart Tube Anterior/posterior Pattern Specification Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Bone Mineralization Involved In Bone Maturation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Fate Commitment Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Astrocyte Differentiation Mesenchymal Cell Differentiation Inner Ear Development Negative Regulation Of Calcium-independent Cell-cell Adhesion Positive Regulation Of DNA-binding Transcription Factor Activity Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Pericardium Development Corticotropin Hormone Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Cardiac Epithelial To Mesenchymal Transition Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Mesenchyme Development Positive Regulation Of Wnt Signaling Pathway By BMP Signaling Pathway Positive Regulation Of Cartilage Development BMP Signaling Pathway Involved In Heart Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Organic Cyclic Compound Cellular Response To BMP Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of P38MAPK Cascade Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Cardiac Jelly Development Atrioventricular Canal Morphogenesis Negative Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Cardiac Muscle Cell Differentiation	MAPK Cascade Vasculogenesis Epithelial To Mesenchymal Transition Neural Tube Closure Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Chondrocyte Differentiation Hematopoietic Progenitor Cell Differentiation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Heart Valve Morphogenesis Aortic Valve Morphogenesis Protein Phosphorylation Protein Export From Nucleus ATP Biosynthetic Process Phosphate-containing Compound Metabolic Process Inflammatory Response Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation SMAD Protein Complex Assembly Salivary Gland Morphogenesis Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Wounding Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Epithelial To Mesenchymal Transition Macrophage Derived Foam Cell Differentiation Positive Regulation Of Fibroblast Migration Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Macrophage Cytokine Production Positive Regulation Of Microglia Differentiation Regulation Of Striated Muscle Tissue Development Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Neural Tube Development Negative Regulation Of Cell-cell Adhesion Hyaluronan Catabolic Process Negative Regulation Of Cell Growth Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Protein-containing Complex Assembly Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Response To Estradiol Response To Progesterone Positive Regulation Of Interleukin-17 Production Receptor Catabolic Process Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Dephosphorylation Regulation Of Cell Population Proliferation Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Vascular Permeability Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Ossification Involved In Bone Remodeling Cell-cell Junction Organization Negative Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cytolysis Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgA Isotypes Lymph Node Development Negative Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Chemotaxis Regulation Of Binding Regulation Of DNA Binding Regulation Of Cell Cycle Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Blood Vessel Remodeling Pathway-restricted SMAD Protein Phosphorylation Regulation Of SMAD Protein Signal Transduction Positive Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Negative Regulation Of Gene Silencing By MiRNA Negative Regulation Of Biomineral Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade Response To Cholesterol Cellular Response To Organic Cyclic Compound Cellular Response To Transforming Growth Factor Beta Stimulus Extracellular Matrix Assembly Positive Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Receptor Signaling Pathway Involved In Heart Development Embryonic Liver Development Positive Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways		Signaling by BMP Molecules associated with elastic fibres Transcriptional regulation by RUNX2 Regulation of RUNX2 expression and activity	Platelet degranulation Influenza Virus Induced Apoptosis Cell surface interactions at the vascular wall Molecules associated with elastic fibres Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Syndecan interactions ECM proteoglycans SMAD2/3 Phosphorylation Motif Mutants in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 Kinase Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer Transcriptional regulation of white adipocyte differentiation UCH proteinases Interleukin-4 and Interleukin-13 signaling RUNX3 regulates CDKN1A transcription Regulation of RUNX3 expression and activity RUNX3 regulates p14-ARF
Drugs			Hyaluronidase (ovine) Terazosin Hyaluronidase (human recombinant) Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Hyaluronidase
Diseases
GWAS		Adult body size ( 32376654) Atrial fibrillation ( 29892015) Axial length ( 24144296) Body mass index ( 19079261 23669352 28892062 25673413) Body size at age 10 ( 32376654) Childhood ear infection ( 27182965) Colorectal cancer ( 25990418 30529582 26151821 29471430 24737748 31826910 23266556) Colorectal cancer or advanced adenoma ( 30510241) Copper levels ( 26025379) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) FEV1 ( 30804560) Heel bone mineral density ( 30598549 28869591) Height ( 20881960 25282103 25429064 23563607 31562340 18391951) Hip circumference adjusted for BMI ( 25673412) Lung function (FVC) ( 28166213 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Major depressive disorder (stressful life events interaction) ( 26845276) Mitochondrial heteroplasmy measurement ( 33731350) Nose morphology (partial least square model) ( 30174134) Obesity-related traits ( 23251661) Optic cup area ( 25631615 31798171 28073927) Peak expiratory flow ( 30804560) Pulse pressure ( 30224653) QRS complex (Cornell) ( 27659466) Refractive error ( 23396134 32231278) Retinal detachment or retinal break ( 31816047) Sagittal craniosynostosis ( 23160099) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels x loop diuretics use interaction ( 31806883) Vertical cup-disc ratio ( 31798171 25241763 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)	Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Colorectal cancer ( 27145994 24836286) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778 28714974 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Hematuria ( 30476138) Hematuria (mild) ( 30476138) Hematuria (moderate to severe) ( 30476138) Platelet count ( 32888494) Preterm birth (maternal effect) ( 28877031) Pulse pressure ( 30578418) Type 2 diabetes ( 31049640)
Interacting Genes		21 interacting genes: ACTR2 ACVR1 ACVR2A ACVR2B ASCL1 BMPER BMPR1A BMPR1B BMPR2 CHRD CHRDL2 COL2A1 ENG GREM1 GREM2 MGP NOG RGMB SOSTDC1 TGFB1 TGFB2	95 interacting genes: ACVRL1 ADAMTSL4 AGR3 ANGPTL4 APC APP AURKA AXIN2 BCAS3 BCL10 BGN BLID BMP2 BMP3 BMPR1A BUB1 CATSPER1 CCDC33 CCL3 CCL5 CCN2 CDKN2A COL2A1 CST6 CYSRT1 DAXX DCN DIRAS3 DLC1 DPT EGFR EIF3I ENG ERBB2 FBXW7 FCHO1 FCN1 FKBP1A FMOD FNTA GREB1 HOXA1 HOXC6 ITGAV ITGB6 ITGB8 KLK5 KLK7 KLK9 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP4-11 LAMTOR5 LCE1A LCE1C LCE1D LCE2B LCE2C LCE3A LCE3B LCE3D LPXN LTBP1 LTBP3 LTBP4 MCC MEOX2 MLH3 MMP2 MTA3 NSD3 P4HB PDGFRL PDLIM2 POU4F2 PRSS50 PSMC3IP PZP RAPGEF3 SCGB3A1 SDC2 SNAI1 SPARC ST14 TGFB2 TGFBR1 TGFBR2 TGFBR3 THBS1 THRSP TLR2 VASN VTN YWHAE
Entrez ID		650	7040
HPRD ID		00206	01821
Ensembl ID		ENSG00000125845	ENSG00000105329
Uniprot IDs		C8C060 P12643	A0A499FJK2 P01137
PDB IDs		1ES7 1REU 1REW 2GOO 2H62 2H64 2QJ9 2QJA 2QJB 3BK3 3BMP 4MID 4N1D 4UHY 4UHZ 4UI0 4UI1 4UI2 6OMN	1KLA 1KLC 1KLD 3KFD 4KV5 5FFO 5VQP 6OM2 6P7J
Enriched GO Terms of Interacting Partners?
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