ADCY2 and NUF2

		ADCY2	NUF2
Description		adenylate cyclase 2	NUF2 component of NDC80 kinetochore complex
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Dendrite Membrane Raft	Chromosome, Centromeric Region Kinetochore Nucleoplasm Cytosol Membrane Ndc80 Complex
	Molecular Function	Magnesium Ion Binding Adenylate Cyclase Activity ATP Binding Adenylate Cyclase Binding Manganese Ion Binding	Molecular_function Protein Binding Protein-containing Complex Binding
	Biological Process	CAMP Biosynthetic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway CAMP-mediated Signaling Cellular Response To Forskolin	Mitotic Spindle Organization Chromosome Segregation Meiotic Chromosome Segregation Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization
Pathways		Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE Aurothioglucose
Diseases
GWAS		Anxiety and stress-related disorders ( 31116379) Atorvastatin-induced myopathy ( 31220337) Bipolar disorder ( 24618891 31043756) Bipolar disorder (age of onset <21) or attention deficit hyperactivity disorder ( 27890468) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Bipolar I disorder ( 31043756) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Capecitabine sensitivity ( 22864933) Coffee consumption ( 31046077) Cognitive decline rate in late mild cognitive impairment ( 26252872) Food addiction ( 27106561) LDL cholesterol levels in HIV infection ( 33109212) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Oropharynx cancer ( 27749845) Pars opercularis volume ( 31530798) Plasma factor VII activating protease levels ( 30070759) Posterior-cingulate cortex volume ( 31530798) Smoking status (heavy vs never) ( 26423011) Visceral fat ( 22589738)	Asthma ( 29273806) Cellular nuclear factor (erythroid-derived 2)-like 2 levels ( 30767168) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Diffusing capacity of carbon monoxide ( 30694715) Height ( 28552196) Myopia ( 27182965)
Interacting Genes		14 interacting genes: ADCY1 ADCY5 AHRR CDH18 DRD4 F2RL1 GCDH GNAS GNG2 ISL1 NUF2 OBP2A RDH12 SLC9A3	13 interacting genes: ADCY2 ATF3 AURKA AURKB AZGP1 CENPE CENPH DTNBP1 EXOC1 FCRLA NDC80 OGT SDCBP2
Entrez ID		108	83540
HPRD ID		00052	10817
Ensembl ID		ENSG00000078295	ENSG00000143228
Uniprot IDs		Q08462 Q71UM8	Q9BZD4
PDB IDs			2VE7 3IZ0
Enriched GO Terms of Interacting Partners?
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