TINF2 and RGS14

Number of citations of the paper that reports this interaction (PubMedID 21044950)
51

Data Source:
BioGRID (two hybrid)

		TINF2	RGS14
Description		TERF1 interacting nuclear factor 2	regulator of G protein signaling 14
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleoplasm Perinucleolar Chromocenter Nuclear Matrix Nuclear Body Shelterin Complex	Spindle Pole Nucleus Cytoplasm Centrosome Spindle Microtubule Plasma Membrane Postsynaptic Density Nuclear Body PML Body Dendrite Dendritic Spine Glutamatergic Synapse
	Molecular Function	DNA Binding Protein Binding Telomeric DNA Binding	G-protein Alpha-subunit Binding GTPase Activity GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Microtubule Binding Protein Kinase Binding Signaling Receptor Complex Adaptor Activity GTPase Activating Protein Binding
	Biological Process	Negative Regulation Of Protein ADP-ribosylation Telomere Capping Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region Regulation Of Telomere Maintenance Via Telomere Lengthening	Mitotic Cell Cycle Nucleocytoplasmic Transport Response To Oxidative Stress Spindle Organization Chromosome Segregation G Protein-coupled Receptor Signaling Pathway Learning Long-term Memory Regulation Of G Protein-coupled Receptor Signaling Pathway Visual Learning Zygote Asymmetric Cell Division Negative Regulation Of Synaptic Plasticity Intracellular Signal Transduction Negative Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Neurogenesis Cell Division Long-term Synaptic Potentiation Negative Regulation Of ERK1 And ERK2 Cascade
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	G alpha (i) signalling events G alpha (i) signalling events
Drugs
Diseases
GWAS		Leukocyte telomere length ( 31171785) Platelet count ( 29403010)	Activated partial thromboplastin time ( 22703881) Allergic disease (asthma, hay fever or eczema) ( 29083406) Blood urea nitrogen levels ( 31152163) Calcium levels ( 24068962) Chronic kidney disease ( 31152163 20383146) Circulating fibroblast growth factor 23 levels ( 30217807) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 31604244 24076602 21833088) Nephrolithiasis ( 22396660) Phosphorus levels ( 29403010) Red blood cell count ( 32888494 27863252) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727) Serum parathyroid hormone levels ( 27927781) Ulcerative colitis ( 28067908) Urolithiasis ( 30975718) Vitamin C levels ( 33203707) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		89 interacting genes: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 ANXA8L1 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CTTN DBN1 DCX DHFR2 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 MTNR1B NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS1 SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790	17 interacting genes: APP GNA11 GNAI1 GNAI2 GNAI3 GNAO1 NFKB1 POT1 PRKACA RAP1A RAP2A SORCS3 TINF2 TRAF2 VIPR2 WAS XPO1
Entrez ID		26277	10636
HPRD ID		16056	03944
Ensembl ID		ENSG00000092330	ENSG00000169220
Uniprot IDs		Q9BSI4	O43566
PDB IDs		3BQO 3BU8 5XYF	2JNU 2OM2 2XNS 3ONW 3QI2
Enriched GO Terms of Interacting Partners?
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