RGS14 and GNAI1

Number of citations of the paper that reports this interaction (PubMedID 11976690)
108

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		RGS14	GNAI1
Description		regulator of G protein signaling 14	G protein subunit alpha i1
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Spindle Microtubule Plasma Membrane Postsynaptic Density Nuclear Body PML Body Dendrite Dendritic Spine Glutamatergic Synapse	Nucleus Cytoplasm Lysosomal Membrane Centrosome Heterotrimeric G-protein Complex Plasma Membrane Midbody Membrane Raft Extracellular Exosome Cell Cortex Region
	Molecular Function	G-protein Alpha-subunit Binding GTPase Activity GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Microtubule Binding Protein Kinase Binding Signaling Receptor Complex Adaptor Activity GTPase Activating Protein Binding	Magnesium Ion Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding GDP Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding GTPase Activating Protein Binding
	Biological Process	Mitotic Cell Cycle Nucleocytoplasmic Transport Response To Oxidative Stress Spindle Organization Chromosome Segregation G Protein-coupled Receptor Signaling Pathway Learning Long-term Memory Regulation Of G Protein-coupled Receptor Signaling Pathway Visual Learning Zygote Asymmetric Cell Division Negative Regulation Of Synaptic Plasticity Intracellular Signal Transduction Negative Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Neurogenesis Cell Division Long-term Synaptic Potentiation Negative Regulation Of ERK1 And ERK2 Cascade	Cell Cycle G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Peptide Hormone Regulation Of CAMP-mediated Signaling Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Mitotic Spindle Organization Cellular Response To Forskolin Positive Regulation Of Protein Localization To Cell Cortex
Pathways		G alpha (i) signalling events G alpha (i) signalling events	Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway ADP signalling through P2Y purinoceptor 12 Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Regulation of insulin secretion Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production
Drugs			Guanosine-5'-Diphosphate Tetrafluoroaluminate Ion
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Allergic disease (asthma, hay fever or eczema) ( 29083406) Blood urea nitrogen levels ( 31152163) Calcium levels ( 24068962) Chronic kidney disease ( 31152163 20383146) Circulating fibroblast growth factor 23 levels ( 30217807) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 31604244 24076602 21833088) Nephrolithiasis ( 22396660) Phosphorus levels ( 29403010) Red blood cell count ( 32888494 27863252) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727) Serum parathyroid hormone levels ( 27927781) Ulcerative colitis ( 28067908) Urolithiasis ( 30975718) Vitamin C levels ( 33203707) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Cognitive decline rate in late mild cognitive impairment ( 26252872) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Nicotine dependence ( 33144568) Night sleep phenotypes ( 27126917) Post bronchodilator FEV1 ( 26634245)
Interacting Genes		17 interacting genes: APP GNA11 GNAI1 GNAI2 GNAI3 GNAO1 NFKB1 POT1 PRKACA RAP1A RAP2A SORCS3 TINF2 TRAF2 VIPR2 WAS XPO1	62 interacting genes: ADCY5 ADRA2A ADRB2 CCR5 CD47 CMKLR2 CNR1 CRHR1 CXCR4 DRD3 DRD4 EPOR ESR1 FFAR1 GNAO1 GNB2 GNB4 GNG2 GPR143 GPSM1 GPSM2 GPSM3 HRH4 HTR2A IGF1R KLHL3 MTNR1A MTNR1B NGB NUCB1 NUMA1 OPRD1 OPRM1 PCP2 PDE6D PTEN PTPRU RANGAP1 RASD1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS20 RGS4 RGS7 RIC8A S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SSTR2 SSTR3 STRN THAP7 TSHR VIPR1 WASF1
Entrez ID		10636	2770
HPRD ID		03944	00756
Ensembl ID		ENSG00000169220	ENSG00000127955
Uniprot IDs		O43566	P63096
PDB IDs		2JNU 2OM2 2XNS 3ONW 3QI2	1KJY 1Y3A 2G83 2GTP 2IK8 2OM2 2XNS 3ONW 3QE0 3QI2 3UMR 3UMS 4G5Q 5JS7 5JS8 5TDH 6CMO 6CRK 6DDE 6DDF 6KPF 6KPG 6LFM 6LFO 6LML 6N4B 6OMM 6OS9 6OSA 6OT0 6PB0 6PB1 6PT0 6QNO 6VU8 6XBJ 6XBK 6XBL 6XBM 7JVR 7L0P 7L0Q 7L0R 7L0S
Enriched GO Terms of Interacting Partners?
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