FBXO8 and TRIP13

Number of citations of the paper that reports this interaction (PubMedID 26871637)
172

Data Source:
BioGRID (two hybrid)

		FBXO8	TRIP13
Description		F-box protein 8	thyroid hormone receptor interactor 13
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex	Male Germ Cell Nucleus Nucleus Chromosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity	Transcription Coregulator Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Regulation Of ARF Protein Signal Transduction Regulation Of Catalytic Activity	Oocyte Maturation Double-strand Break Repair Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Mitotic Spindle Assembly Checkpoint Signaling Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiosis I Female Meiosis I Spermatogenesis Spermatid Development Oogenesis Meiotic Recombination Checkpoint Signaling
Pathways
Drugs
Diseases
GWAS		Chin dimples ( 27182965) Copper levels ( 26025379) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Pancreatic cancer ( 25086665)
Interacting Genes		7 interacting genes: CDK4 GPM6A HIF1A MTOR MYC SKP1 TRIP13	113 interacting genes: ADAM15 AMDHD2 ANKRD10 ARL11 ARSA ASB13 BUB1B C11orf54 C19orf54 C4orf33 CARD14 CD99 CDC20 CDIN1 CEP170B CFP CLIP4 COMT CRMP1 CRYBA2 CYB5R2 DCTN3 DDAH2 DIP2A DPYSL4 DTX2 EEF2KMT FBLN5 FBXO8 FNDC3B GALT GLYCTK GPRIN2 GPSM1 HDHD3 IGFN1 IL2RB INCA1 INTS11 KRTAP12-1 KRTAP12-2 KRTAP12-4 KRTAP26-1 KRTAP3-2 KRTAP6-1 KRTAP6-2 KYAT1 LASP1 LNX1 LOXL4 LRR1 LRRC61 M1AP MAD2L1 MAD2L1BP MBLAC1 MEAK7 METTL15 MFGE8 MGAT5B MORN3 MPPED2 MVP MYEOV NIF3L1 NME4 NTAQ1 PARP11 PAX9 PBLD PCMTD2 PCSK5 PELI1 PLAC8 PLK3 PLSCR3 PLSCR4 POLR2L PPP2CA PRKAA2 PRKN PRR13 PSMB8 QARS1 RBPMS RHOXF2 RNF4 SCP2 SDCBP SEC24A SELENBP1 SEMA3B SEMA4G SHARPIN SIGLEC5 SMUG1 SPRYD7 SSC4D STAMBP STAMBPL1 SUMO2 TENT5B TEX37 THRB TINAGL1 TNRC6A TPT1 UBE2I VDR VENTX ZMYM5 ZNF34 ZNF655
Entrez ID		26269	9319
HPRD ID		07293	05145
Ensembl ID		ENSG00000164117	ENSG00000071539
Uniprot IDs		A0A0S2Z5D1 Q8IXA8 Q9NRD0	Q15645
PDB IDs			5VQ9 5VQA 5WC2 6F0X 6LK0 7L9P
Enriched GO Terms of Interacting Partners?
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