PHGDH and PJA1

Number of citations of the paper that reports this interaction (PubMedID 21461837)
7

Data Source:
BioGRID (enzymatic study)

		PHGDH	PJA1
Description		phosphoglycerate dehydrogenase	praja ring finger ubiquitin ligase 1
Image
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Cytoplasm
	Molecular Function	Phosphoglycerate Dehydrogenase Activity Electron Transfer Activity L-malate Dehydrogenase Activity NAD Binding	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Glutamine Metabolic Process Glycine Metabolic Process L-serine Biosynthetic Process Threonine Metabolic Process Brain Development Gamma-aminobutyric Acid Metabolic Process Regulation Of Gene Expression Taurine Metabolic Process Spinal Cord Development Glial Cell Development Neural Tube Development Electron Transport Chain Neuron Projection Development G1 To G0 Transition	Protein Ubiquitination Protein Catabolic Process
Pathways		Serine biosynthesis	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		NADH
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Amino acid levels ( 26068415) Blood metabolite levels ( 24816252) Glycine levels ( 31070104 30837465) Height ( 25282103) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Macular telangiectasia type 2 ( 28250457 33654266) Mean corpuscular hemoglobin ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic traits ( 21886157) Metabolite levels ( 23378610) Multiple sclerosis ( 31604244 24076602) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Red blood cell count ( 32888494 27863252) Serum metabolite levels ( 33031748) Severe gingival inflammation ( 28459102) Total cholesterol levels ( 30275531)	Birth weight ( 31043758) Body mass index ( 29273807) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		10 interacting genes: APP CHMP2B LINC01554 MAPK6 OGT PIAS4 PJA1 SIRT2 SUMO4 TTN	64 interacting genes: ABR ASCC2 ATP5F1C ATXN3 ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 EED ELAC1 ESPL1 EZH2 FGF12 GATD3 GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 OTUB2 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440
Entrez ID		26227	64219
HPRD ID		06047	02335
Ensembl ID		ENSG00000092621	ENSG00000181191
Uniprot IDs		O43175	Q8NG27
PDB IDs		2G76 5N53 5N6C 5NZO 5NZP 5NZQ 5OFM 5OFV 5OFW 6CWA 6PLF 6PLG 6RIH 6RJ2 6RJ3 6RJ5 6RJ6 7CVP	2L0B
Enriched GO Terms of Interacting Partners?
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