PHGDH

Description		phosphoglycerate dehydrogenase
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome
	Molecular Function	Phosphoglycerate Dehydrogenase Activity Electron Transfer Activity L-malate Dehydrogenase Activity NAD Binding
	Biological Process	Glutamine Metabolic Process Glycine Metabolic Process L-serine Biosynthetic Process Threonine Metabolic Process Brain Development Gamma-aminobutyric Acid Metabolic Process Regulation Of Gene Expression Taurine Metabolic Process Spinal Cord Development Glial Cell Development Neural Tube Development Electron Transport Chain Neuron Projection Development G1 To G0 Transition
Pathways		Serine biosynthesis
Drugs		NADH
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Amino acid levels ( 26068415) Blood metabolite levels ( 24816252) Glycine levels ( 31070104 30837465) Height ( 25282103) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Macular telangiectasia type 2 ( 28250457 33654266) Mean corpuscular hemoglobin ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic traits ( 21886157) Metabolite levels ( 23378610) Multiple sclerosis ( 31604244 24076602) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Red blood cell count ( 32888494 27863252) Serum metabolite levels ( 33031748) Severe gingival inflammation ( 28459102) Total cholesterol levels ( 30275531)
Interacting Genes		10 interacting genes: APP CHMP2B LINC01554 MAPK6 OGT PIAS4 PJA1 SIRT2 SUMO4 TTN
Entrez ID		26227
HPRD ID		06047
Ensembl ID		ENSG00000092621
Uniprot IDs		O43175
PDB IDs		2G76 5N53 5N6C 5NZO 5NZP 5NZQ 5OFM 5OFV 5OFW 6CWA 6PLF 6PLG 6RIH 6RJ2 6RJ3 6RJ5 6RJ6 7CVP
Enriched GO Terms of Interacting Partners?
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