HACL1 and MAPK6

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		HACL1	MAPK6
Description		2-hydroxyacyl-CoA lyase 1	mitogen-activated protein kinase 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Peroxisome Peroxisomal Matrix Cytosol Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex
	Molecular Function	Magnesium Ion Binding Protein Binding ATP Binding Carbon-carbon Lyase Activity Thiamine Pyrophosphate Binding Identical Protein Binding 2-hydroxy-3-methylhexadecanoyl-CoA Lyase Activity 2-hydroxyphytanoyl-CoA Lyase Activity	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Heterodimerization Activity Protein Serine Kinase Activity
	Biological Process	Fatty Acid Alpha-oxidation Protein Targeting To Peroxisome Fatty Acid Metabolic Process Methyl-branched Fatty Acid Metabolic Process Phytanic Acid Metabolic Process	MAPK Cascade Protein Phosphorylation Cell Cycle Signal Transduction Intracellular Signal Transduction Positive Regulation Of Dendritic Spine Development
Pathways		Alpha-oxidation of phytanate Peroxisomal protein import Peroxisomal protein import	MAPK6/MAPK4 signaling
Drugs			Acetylsalicylic acid Minocycline
Diseases
GWAS			Frailty index ( 34431594) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		4 interacting genes: MAGEB6 MAPK6 PEX5 ZMYND19	167 interacting genes: ACTG1 ACTR1B AMPH ANAPC5 ANK3 ANKRD2 APBA2 ARHGDIA ARPC3 ATG9A ATP5PF BAG6 BARX1 BBS10 CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFAP298 CFL1 CNTN1 CNTRL COPS6 CSE1L CYRIB CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DST DYNC2I2 EDF1 EEF1A2 EIF1 EIF3C EIF4A1 ELOF1 EMD FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NAXE NDUFS6 NECTIN2 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 RAB2A RAB31 RACK1 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPTIN3 SEPTIN5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TCF12 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 USP20 VPS26C WDR26 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775
Entrez ID		26061	5597
HPRD ID		09183	04213
Ensembl ID		ENSG00000131373	ENSG00000069956
Uniprot IDs		B4DXR1 Q9UJ83	Q16659
PDB IDs			6YKY 6YLC 6YLL 7AQB
Enriched GO Terms of Interacting Partners?
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