MAPK6 and CYTH2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		MAPK6	CYTH2
Description		mitogen-activated protein kinase 6	cytohesin 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex	Golgi Membrane Cytoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Membrane Growth Cone
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Heterodimerization Activity Protein Serine Kinase Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Cell Cycle Signal Transduction Intracellular Signal Transduction Positive Regulation Of Dendritic Spine Development	Endocytosis Actin Cytoskeleton Organization Regulation Of ARF Protein Signal Transduction Regulation Of Catalytic Activity
Pathways		MAPK6/MAPK4 signaling	Intra-Golgi traffic
Drugs		Acetylsalicylic acid Minocycline	Inositol 1,3,4,5-Tetrakisphosphate Formic acid 1D-myo-inositol 1,4,5-trisphosphate S,S-(2-Hydroxyethyl)Thiocysteine Brefeldin A
Diseases
GWAS		Frailty index ( 34431594) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Abstraction and mental flexibility ( 31596458)
Interacting Genes		167 interacting genes: ACTG1 ACTR1B AMPH ANAPC5 ANK3 ANKRD2 APBA2 ARHGDIA ARPC3 ATG9A ATP5PF BAG6 BARX1 BBS10 CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFAP298 CFL1 CNTN1 CNTRL COPS6 CSE1L CYRIB CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DST DYNC2I2 EDF1 EEF1A2 EIF1 EIF3C EIF4A1 ELOF1 EMD FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NAXE NDUFS6 NECTIN2 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 RAB2A RAB31 RACK1 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPTIN3 SEPTIN5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TCF12 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 USP20 VPS26C WDR26 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775	33 interacting genes: ADORA2A ALDOA APC ARF1 ARF6 ARFGAP1 ARL4A ARL4D ARRB1 ARRB2 ATP6V0A1 ATP6V0A2 ATP6V0A4 CCDC120 CNKSR1 CUX1 CYTIP DOCK1 GGA3 GNAQ INAVA IPCEF1 ITGB2 MAPK6 NUP62 PIK3CA PNPLA2 PRKCA PRKCB PRKCG PRRG2 TCIRG1 TRIM23
Entrez ID		5597	9266
HPRD ID		04213	03925
Ensembl ID		ENSG00000069956	ENSG00000105443
Uniprot IDs		Q16659	Q99418
PDB IDs		6YKY 6YLC 6YLL 7AQB	1PBV 1R8M 1R8Q 1R8S 1S9D 4JMI 4JMO 4JWL 4JXH 4L5M 4Z21
Enriched GO Terms of Interacting Partners?
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