NELFB and NTRK3

Number of citations of the paper that reports this interaction (PubMedID 24034695)
9

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		NELFB	NTRK3
Description		negative elongation factor complex member B	neurotrophic receptor tyrosine kinase 3
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm NELF Complex	Plasma Membrane Integral Component Of Plasma Membrane Axon Receptor Complex Glutamatergic Synapse Integral Component Of Postsynaptic Membrane
	Molecular Function	RNA Binding Protein Binding	P53 Binding Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Neurotrophin Receptor Activity Protein Binding ATP Binding Neurotrophin Binding
	Biological Process	Cell Population Proliferation Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Stem Cell Differentiation Negative Regulation Of Stem Cell Differentiation	Neuron Migration Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Heart Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Activation Of Protein Kinase B Activity Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Kinase Activity Neurotrophin Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Response To Ethanol Ephrin Receptor Signaling Pathway Neuron Fate Specification Response To Axon Injury Negative Regulation Of Astrocyte Differentiation Positive Regulation Of Positive Chemotaxis Response To Corticosterone Regulation Of Protein Kinase B Signaling Negative Regulation Of Cell Death Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cochlea Development Activation Of GTPase Activity Regulation Of Postsynaptic Density Assembly Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation NTRK3 as a dependence receptor	Receptor-type tyrosine-protein phosphatases NTF3 activates NTRK3 signaling NTF3 activates NTRK3 signaling Signaling by NTRK3 (TRKC) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through RAS Activated NTRK3 signals through PI3K Activated NTRK3 signals through PI3K NTRK3 as a dependence receptor
Drugs			Entrectinib Fostamatinib Larotrectinib Pralsetinib
Diseases
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576) Diabetic peripheral neuropathy in type 2 diabetes ( 31127053) Gaucher disease severity ( 22388998) General risk tolerance (MTAG) ( 30643258)
Interacting Genes		17 interacting genes: BRCA1 CEBPE DENR ESR1 EXOSC2 FOS HSPA9 JUN KHDRBS3 MAPK6 MGST1 NELFE NTRK3 RAD51 TPRX1 TUBB4B WDR5	28 interacting genes: APP BEX3 DOK5 DOK6 DYNLL1 ERBB2 FRS2 HEY1 HTR2A IRAK1 IRAK3 JUN KIDINS220 KPNA4 MAPK1 MAPK3 NELFB NGFR NSD1 NTF3 PLCG1 PTPN1 RASGRF1 SHC1 SHC2 SORT1 SQSTM1 WDR13
Entrez ID		25920	4916
HPRD ID		10845	01870
Ensembl ID		ENSG00000188986	ENSG00000140538
Uniprot IDs		Q8WX92	B7Z7U4 O95193 Q16288 Q96CY4 X5D2R1 X5D7M5 X5DNW6
PDB IDs		6GML	1WWC 3V5Q 4YMJ 6KZC 6KZD
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?