NIPBL and TRIO

		NIPBL	TRIO
Description		NIPBL cohesin loading factor	trio Rho guanine nucleotide exchange factor
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Integrator Complex SMC Loading Complex Intracellular Membrane-bounded Organelle Extracellular Exosome Scc2-Scc4 Cohesin Loading Complex	Cytosol Cell Projection
	Molecular Function	Chromatin Binding Protein Binding Protein C-terminus Binding Mediator Complex Binding Histone Deacetylase Binding Protein N-terminus Binding Chromo Shadow Domain Binding Promoter-specific Chromatin Binding	Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Metanephros Development Heart Morphogenesis Outflow Tract Morphogenesis Cellular Response To DNA Damage Stimulus Mitotic Sister Chromatid Cohesion Brain Development Sensory Perception Of Sound Stem Cell Population Maintenance Positive Regulation Of Histone Deacetylation Establishment Of Mitotic Sister Chromatid Cohesion Maintenance Of Mitotic Sister Chromatid Cohesion Cellular Protein Localization Embryonic Forelimb Morphogenesis Forelimb Morphogenesis External Genitalia Morphogenesis Positive Regulation Of Multicellular Organism Growth Ear Morphogenesis Regulation Of Hair Cycle Fat Cell Differentiation Positive Regulation Of Ossification Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Embryonic Digestive Tract Morphogenesis Digestive Tract Development Developmental Growth Eye Morphogenesis Regulation Of Developmental Growth Embryonic Viscerocranium Morphogenesis Cognition Face Morphogenesis Gall Bladder Development Uterus Morphogenesis Mitotic Cohesin Loading Establishment Of Protein Localization To Chromatin Cellular Response To X-ray Cohesin Loading Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Positive Regulation Of Neuron Migration	Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Axon Guidance Central Nervous System Development Negative Regulation Of Fat Cell Differentiation Neuron Projection Morphogenesis Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Cohesin Loading onto Chromatin	NRAGE signals death through JNK G alpha (q) signalling events G alpha (12/13) signalling events DCC mediated attractive signaling DCC mediated attractive signaling RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Height ( 28552196 25282103 31562340) Malaria ( 31844061) Meat-related diet ( 32066663) Obesity-related traits ( 23251661) Weight ( 28552196)	Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel) ( 24025145) Antidepressant treatment resistance (number of drugs prescribed) ( 30700811) Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Electroencephalogram traits ( 25387704) High density lipoprotein cholesterol levels ( 30498476) Intake of total sugars ( 31005972) Major depressive disorder ( 27777418) Paclitaxel-induced neuropathy ( 23776197) Physiological dysregulation (Mahalanobis distance) ( 32235003) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417) Waist circumference ( 28552196)
Interacting Genes		8 interacting genes: CBX5 CDK6 DBN1 HINFP PRSS23 SP100 SUMO2 TRIO	17 interacting genes: BLMH CDC42 CDC5L DAP DISC1 DNAH5 EXOC1 FLNA ITSN2 LIMS1 MARCHF6 NIPBL PRMT7 PTK2 PTPRF RAC1 RHOA
Entrez ID		25836	7204
HPRD ID		10560	03537
Ensembl ID		ENSG00000164190	ENSG00000038382
Uniprot IDs		A0A590UJS4 Q6KC79	O75962
PDB IDs		6WG3 6WGE	1NTY 2NZ8 6D8Z
Enriched GO Terms of Interacting Partners?
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