CNGB1 and ABCA4

Number of citations of the paper that reports this interaction (PubMedID 10466724)
44

Data Source:
HPRD (in vivo)

		CNGB1	ABCA4
Description		cyclic nucleotide gated channel subunit beta 1	ATP binding cassette subfamily A member 4
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Plasma Membrane Intracellular Cyclic Nucleotide Activated Cation Channel Complex Golgi-associated Vesicle Membrane Terminal Bouton Ciliary Membrane Transmembrane Transporter Complex	Photoreceptor Outer Segment Endoplasmic Reticulum Integral Component Of Plasma Membrane Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Photoreceptor Disc Membrane Rod Photoreceptor Disc Membrane
	Molecular Function	Intracellular CAMP-activated Cation Channel Activity Intracellular CGMP-activated Cation Channel Activity Protein Binding Ligand-gated Ion Channel Activity CAMP Binding CGMP Binding Protein-containing Complex Binding	GTPase Activity Transporter Activity Lipid Transporter Activity Retinoid Binding 11-cis Retinal Binding All-trans Retinal Binding ATP Binding Phospholipid Transporter Activity ATP Hydrolysis Activity Retinol Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Phosphatidylethanolamine Flippase Activity ATPase-coupled Intramembrane Lipid Transporter Activity Flippase Activity N-retinylidene-phosphatidylethanolamine Flippase Activity ABC-type Transporter Activity
	Biological Process	Retina Homeostasis Cation Transport Visual Perception Phototransduction Positive Regulation Of Gene Expression Olfactory Nerve Maturation Protein Localization To Organelle Photoreceptor Cell Outer Segment Organization Photoreceptor Cell Maintenance Detection Of Light Stimulus Involved In Visual Perception Detection Of Chemical Stimulus Involved In Sensory Perception Of Smell Regulation Of Cytosolic Calcium Ion Concentration Membrane Depolarization Cation Transmembrane Transport Ion Channel Modulating, G Protein-coupled Receptor Signaling Pathway Response To Odorant	Retinoid Metabolic Process Phospholipid Transfer To Membrane Lipid Transport Visual Perception Phototransduction, Visible Light Retinol Transport Retinal Metabolic Process Phospholipid Translocation Photoreceptor Cell Maintenance Transmembrane Transport
Pathways		Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium	Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision) The canonical retinoid cycle in rods (twilight vision) ABC-family proteins mediated transport
Drugs
Diseases
GWAS		Initial alcohol sensitivity ( 30276832) Low density lipoprotein cholesterol levels ( 32154731) Prudent dietary pattern ( 28644415) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552) Triglyceride levels ( 32154731)	D-dimer levels ( 21502573) Dialysis-related mortality ( 21546767) Nonsyndromic cleft lip with cleft palate ( 28232668) Palmitoleic acid (16:1n-7) levels ( 23362303) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: ABCA4 PNN PRPH2	2 interacting genes: ATP1A3 CNGB1
Entrez ID		1258	24
HPRD ID		07204	03408
Ensembl ID		ENSG00000070729	ENSG00000198691
Uniprot IDs		Q14028	P78363 Q6AI28
PDB IDs			7LKP 7LKZ
Enriched GO Terms of Interacting Partners?
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