DDX58 and USP15

Number of citations of the paper that reports this interaction (PubMedID 26061460)
24

Data Source:
BioGRID (pull down)

		DDX58	USP15
Description		DExD/H-box helicase 58	ubiquitin specific peptidase 15
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Actin Cytoskeleton Ruffle Membrane Ribonucleoprotein Complex	Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane
	Molecular Function	RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding ATP Binding Zinc Ion Binding ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding Identical Protein Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Transforming Growth Factor Beta Receptor Binding Protein Binding Identical Protein Binding SMAD Binding Ubiquitin Modification-dependent Histone Binding Lys48-specific Deubiquitinase Activity
	Biological Process	Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Detection Of Virus Response To Virus Positive Regulation Of Gene Expression Regulation Of Cell Migration Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Type III Interferon Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus RIG-I Signaling Pathway Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Antiviral Innate Immune Response	Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Protein Deubiquitination BMP Signaling Pathway Monoubiquitinated Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination Pathway-restricted SMAD Protein Phosphorylation Protein K48-linked Deubiquitination Positive Regulation Of RIG-I Signaling Pathway Negative Regulation Of Antifungal Innate Immune Response Protein K27-linked Deubiquitination
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases OAS antiviral response TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling	Downregulation of TGF-beta receptor signaling UCH proteinases Ub-specific processing proteases
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Bone mineral density (spine) and age at menarche ( 26312577) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Inflammatory skin disease ( 25574825) Metabolite levels ( 23823483) Psoriasis ( 25903422 25574825 23143594) Psoriasis or type 2 diabetes (trans-disease meta-analysis) ( 33385400) Psoriasis vulgaris ( 26626624) Red blood cell count ( 27863252)	Alopecia areata ( 25608926) Metabolite levels ( 23823483) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Pulmonary function decline ( 22424883) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271)
Interacting Genes		19 interacting genes: CCDC50 CYLD MAVS PKD1 PRKCG RNF122 RNF135 SNX5 THAP12 TRIM25 TRIM40 TRIM65 UBC UBE2D1 UBE2D2 UBE2D3 USP15 USP3 VPS26C	55 interacting genes: BAP1 BMI1 BMPR1A BRAP CARD9 CCDC57 CDK4 DDX58 FHL1 GEMIN4 GOLGA2 GOLGA6A H2BC21 IL1R2 JOSD1 KEAP1 MAD1L1 MDC1 MDM2 OTUB1 PHF7 PIBF1 PLA2G2A PRPF31 RBCK1 RNF126 RNF144B SENP3 SENP8 SMURF2 SPDL1 STAM STK33 SYVN1 TEX11 TRAF6 TRIM17 TRIM21 TRIM25 TRIM46 TRIM5 TRIM54 TRIM63 TRIM74 UCHL1 UCHL3 USP14 USP2 USP20 USP21 USP28 USP33 USP51 USP8 YOD1
Entrez ID		23586	9958
HPRD ID		13131	05293
Ensembl ID		ENSG00000107201	ENSG00000135655
Uniprot IDs		O95786	Q9Y4E8
PDB IDs		2LWD 2LWE 2QFB 2QFD 2RMJ 2YKG 3LRN 3LRR 3NCU 3OG8 3ZD6 3ZD7 4AY2 4BPB 4NQK 4ON9 4P4H 5E3H 5F98 5F9F 5F9H 6GPG 6KYV 7JL1 7JL3	1W6V 3LMN 3PPA 3PV1 3T9L 4A3O 4A3P 5JJW 6CPM 6CRN 6DJ9 6GH9 6GHA 6ML1
Enriched GO Terms of Interacting Partners?
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