DDX58

Description		DExD/H-box helicase 58
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Actin Cytoskeleton Ruffle Membrane Ribonucleoprotein Complex
	Molecular Function	RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Protein Binding ATP Binding Zinc Ion Binding ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Detection Of Virus Response To Virus Positive Regulation Of Gene Expression Regulation Of Cell Migration Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Type III Interferon Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus RIG-I Signaling Pathway Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Antiviral Innate Immune Response
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases OAS antiviral response TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Bone mineral density (spine) and age at menarche ( 26312577) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Inflammatory skin disease ( 25574825) Metabolite levels ( 23823483) Psoriasis ( 25903422 25574825 23143594) Psoriasis or type 2 diabetes (trans-disease meta-analysis) ( 33385400) Psoriasis vulgaris ( 26626624) Red blood cell count ( 27863252)
Interacting Genes		19 interacting genes: CCDC50 CYLD MAVS PKD1 PRKCG RNF122 RNF135 SNX5 THAP12 TRIM25 TRIM40 TRIM65 UBC UBE2D1 UBE2D2 UBE2D3 USP15 USP3 VPS26C
Entrez ID		23586
HPRD ID		13131
Ensembl ID		ENSG00000107201
Uniprot IDs		O95786
PDB IDs		2LWD 2LWE 2QFB 2QFD 2RMJ 2YKG 3LRN 3LRR 3NCU 3OG8 3ZD6 3ZD7 4AY2 4BPB 4NQK 4ON9 4P4H 5E3H 5F98 5F9F 5F9H 6GPG 6KYV 7JL1 7JL3
Enriched GO Terms of Interacting Partners?
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