PADI4 and OTUD3

		PADI4	OTUD3
Description		peptidyl arginine deiminase 4	OTU deubiquitinase 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Cytoplasm Cytosol
	Molecular Function	Protein-arginine Deiminase Activity Calcium Ion Binding Protein Binding Arginine Binding Identical Protein Binding	Thiol-dependent Deubiquitinase Protein Binding
	Biological Process	Chromatin Organization Nucleosome Assembly Chromatin Remodeling Cellular Protein Modification Process Protein Citrullination Stem Cell Population Maintenance Histone H3-R26 Citrullination Histone Citrullination Innate Immune Response	Protein Deubiquitination Protein K11-linked Deubiquitination Protein K6-linked Deubiquitination Protein Stabilization Negative Regulation Of Protein Kinase B Signaling Protein K48-linked Deubiquitination Protein K27-linked Deubiquitination
Pathways		Chromatin modifying enzymes	Ovarian tumor domain proteases Regulation of PTEN stability and activity
Drugs		Citrulline Azithromycin Tetracycline Streptomycin N-[(1S)-1-(aminocarbonyl)-4-(ethanimidoylamino)butyl]benzamide
Diseases
GWAS		Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 18849993) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) IgA nephropathy ( 32912934 25305756) Rheumatoid arthritis ( 21452313 32723749 21505073 30423114 30572963 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)	Group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 19915572 28067908 20228798 20228799 19122664 23511034)
Interacting Genes		13 interacting genes: ANXA4 APP FBXO25 H3C15 HDAC2 LRRK2 NPM1 OTUD3 PADI2 POU6F2 SMURF1 SZRD1 TRIB3	9 interacting genes: EMC1 HSD17B14 HSPA5 PADI4 PTEN STUB1 TP53 UBC UBE2L3
Entrez ID		23569	23252
HPRD ID		05635	19417
Ensembl ID		ENSG00000159339	ENSG00000169914
Uniprot IDs		Q9UM07	Q5T2D3
PDB IDs		1WD8 1WD9 1WDA 2DEW 2DEX 2DEY 2DW5 3APM 3APN 3B1T 3B1U 4DKT 4X8C 4X8G 5N0M 5N0Y 5N0Z 5N1B	4BOU
Enriched GO Terms of Interacting Partners?
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