PADI4 and PADI2

		PADI4	PADI2
Description		peptidyl arginine deiminase 4	peptidyl arginine deiminase 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Extracellular Region Nucleus Cytoplasm Cytosol Transcriptionally Active Chromatin Azurophil Granule Lumen Extracellular Exosome
	Molecular Function	Protein-arginine Deiminase Activity Calcium Ion Binding Protein Binding Arginine Binding Identical Protein Binding	Protein-arginine Deiminase Activity Calcium Ion Binding Estrogen Receptor Binding Protein Homodimerization Activity
	Biological Process	Chromatin Organization Nucleosome Assembly Chromatin Remodeling Cellular Protein Modification Process Protein Citrullination Stem Cell Population Maintenance Histone H3-R26 Citrullination Histone Citrullination Innate Immune Response	Regulation Of Chromatin Disassembly Protein Citrullination Substantia Nigra Development Intracellular Estrogen Receptor Signaling Pathway Histone H3-R26 Citrullination Histone Citrullination Chromatin-mediated Maintenance Of Transcription Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of Lymphocyte Chemotaxis Cellular Response To Leukemia Inhibitory Factor
Pathways		Chromatin modifying enzymes	Chromatin modifying enzymes Neutrophil degranulation
Drugs		Citrulline Azithromycin Tetracycline Streptomycin N-[(1S)-1-(aminocarbonyl)-4-(ethanimidoylamino)butyl]benzamide	Citrulline
Diseases
GWAS		Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 18849993) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) IgA nephropathy ( 32912934 25305756) Rheumatoid arthritis ( 21452313 32723749 21505073 30423114 30572963 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)	Body shape index ( 34021172) Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae) ( 33208821) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Prudent dietary pattern ( 28644415) Rheumatoid arthritis ( 30423114) Visceral fat ( 30942860) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)
Interacting Genes		13 interacting genes: ANXA4 APP FBXO25 H3C15 HDAC2 LRRK2 NPM1 OTUD3 PADI2 POU6F2 SMURF1 SZRD1 TRIB3	2 interacting genes: EMC1 PADI4
Entrez ID		23569	11240
HPRD ID		05635	06396
Ensembl ID		ENSG00000159339	ENSG00000117115
Uniprot IDs		Q9UM07	Q9Y2J8
PDB IDs		1WD8 1WD9 1WDA 2DEW 2DEX 2DEY 2DW5 3APM 3APN 3B1T 3B1U 4DKT 4X8C 4X8G 5N0M 5N0Y 5N0Z 5N1B	4N20 4N22 4N24 4N25 4N26 4N28 4N2A 4N2B 4N2C 4N2D 4N2E 4N2F 4N2G 4N2H 4N2I 4N2K 4N2L 4N2M 4N2N
Enriched GO Terms of Interacting Partners?
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