GCAT and TEAD1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		GCAT	TEAD1
Description		glycine C-acetyltransferase	TEA domain transcription factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Nuclear Speck	Chromatin Nucleoplasm Transcription Regulator Complex TEAD-YAP Complex
	Molecular Function	Glycine C-acetyltransferase Activity Pyridoxal Phosphate Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cellular Amino Acid Metabolic Process Biosynthetic Process L-threonine Catabolic Process To Glycine	Regulation Of Transcription By RNA Polymerase II Hippo Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Protein-containing Complex Assembly Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Pathways		Threonine catabolism	YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs		Pyridoxal phosphate Glycine
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Mean corpuscular volume ( 32888494)	Age at first sexual intercourse ( 34211149) Central retinal vein equivalent ( 26567291) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diisocyanate-induced asthma ( 25918132) Gut microbiota relative abundance (unclassified genus belonging to family Erysipelotrichaceae) ( 33208821) HDL cholesterol levels x loop diuretics use interaction ( 31806883) Heel bone mineral density ( 30598549) Height ( 28552196 20881960 25282103) Hip circumference adjusted for BMI ( 34021172) HOMA-B (corrected for HOMA-IR) ( 30369944) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil count ( 32888494) Rheumatic heart disease ( 34106200)
Interacting Genes		3 interacting genes: MDM2 TDH TEAD1	21 interacting genes: BORCS8-MEF2B ENO1 GCAT HLA-DMB INSR MAX MEF2A MEF2C MYH7 NCOA1 SRF TBP TRIM3 UBTD1 VGLL1 VGLL2 VGLL3 VGLL4 WWTR1 YAP1 ZDHHC17
Entrez ID		23464	7003
HPRD ID		07602	01802
Ensembl ID		ENSG00000100116	ENSG00000187079
Uniprot IDs		A8K228 O75600	P28347 Q59EF3
PDB IDs			2HZD 3KYS 4RE1 4Z8E 5NNX 6HIL 6IM5 7CMM
Enriched GO Terms of Interacting Partners?
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