NCS1 and SIGLEC9

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		NCS1	SIGLEC9
Description		neuronal calcium sensor 1	sialic acid binding Ig like lectin 9
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Postsynaptic Density Dendrite Dense Core Granule Intracellular Membrane-bounded Organelle Calyx Of Held Perinuclear Region Of Cytoplasm Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol	Plasma Membrane Integral Component Of Plasma Membrane Secretory Granule Membrane
	Molecular Function	Magnesium Ion Binding Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding Protein Kinase Binding Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels	Protein Binding Carbohydrate Binding Sialic Acid Binding
	Biological Process	Regulation Of Neuron Projection Development Positive Regulation Of Exocytosis Phosphatidylinositol-mediated Signaling Calcium Ion Transmembrane Transport Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Synaptic Vesicle Exocytosis	Cell Adhesion Cell Surface Receptor Signaling Pathway
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Tuberculosis ( 30713548)	Blood protein levels ( 29875488 28240269) Body mass index ( 29273807) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		28 interacting genes: C1QTNF2 CDSN CEP89 CREM CTAG1A CTAG1B DRD2 DRD3 DRD5 DTX2 EXOSC2 FZD7 GRK2 IL1RAPL1 KCND2 LY6G6D MEOX2 MIEF2 NBL1 OXER1 PI4KB PRDM4 RNASEH1 SFTPA2 SIGLEC9 SPP1 SPRED2 ZC3H10	5 interacting genes: BRICD5 LGALS3BP NCS1 SFTPC TIMM8B
Entrez ID		23413	27180
HPRD ID		04500	16133
Ensembl ID		ENSG00000107130	ENSG00000129450
Uniprot IDs		A0A024R8B2 P62166	Q9Y336
PDB IDs		1G8I 2LCP 4GUK 5O9S 6QI4
Enriched GO Terms of Interacting Partners?
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