SIK3 and CRTC2

Number of citations of the paper that reports this interaction (PubMedID 16306228)
49

Data Source:
HPRD (in vitro, in vivo)

		SIK3	CRTC2
Description		SIK family kinase 3	CREB regulated transcription coactivator 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Cytoplasm Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	Chromatin Binding Protein Binding CAMP Response Element Binding Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Protein Phosphorylation Intracellular Signal Transduction Positive Regulation Of TORC1 Signaling Positive Regulation Of TORC2 Signaling	Gluconeogenesis Positive Regulation Of CREB Transcription Factor Activity Glucose Homeostasis Histone H3-K9 Acetylation Positive Regulation Of Transcription By RNA Polymerase II Protein Homotetramerization Toxin Transport
Pathways			Transcriptional activation of mitochondrial biogenesis Circadian Clock Heme signaling
Drugs		Fostamatinib
Diseases
GWAS		Allergic rhinitis ( 30013184) Apolipoprotein B levels ( 32203549) Blood protein levels ( 28240269) Body mass index ( 31978080) Cholesterol ( 31902109) Delirium ( 29631748) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494 27863252) HDL cholesterol ( 31170924 24886709) HDL cholesterol levels ( 32203549) HDL levels x fish oil supplementation interaction (2df) ( 33760818) Hearing function ( 25060954) Mean platelet volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Metabolic syndrome ( 30382898) Non-accommodative esotropia ( 30098192) Platelet count ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278) Response to Vitamin E supplementation ( 22437554) Sum eosinophil basophil counts ( 27863252) Triglyceride levels ( 32203549 29615537) Triglyceride levels x fish oil supplementation interaction (2df) ( 33760818) Triglycerides ( 24886709)	Age at first birth ( 34211149 27798627) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Empathy quotient ( 29527006) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Raw vegetable consumption ( 32066663) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		7 interacting genes: ATP5MG CRTC2 HDAC5 PRKACA TRAF1 TRIP6 YWHAZ	14 interacting genes: ATPAF2 CCDC57 CDC23 CREB1 MFHAS1 PPP3CA PRKAA1 SIK1 SIK2 SIK3 SUFU YWHAB YWHAG YWHAZ
Entrez ID		23387	200186
HPRD ID		11121	12347
Ensembl ID		ENSG00000160584	ENSG00000160741
Uniprot IDs		A1A5A9 Q9Y2K2	Q53ET0
PDB IDs			4HTM
Enriched GO Terms of Interacting Partners?
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