SYNE1 and AKAP12

		SYNE1	AKAP12
Description		spectrin repeat containing nuclear envelope protein 1	A-kinase anchoring protein 12
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytoskeleton Integral Component Of Membrane Sarcomere Nuclear Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Postsynaptic Membrane	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Neuronal Cell Body Schaffer Collateral - CA1 Synapse
	Molecular Function	RNA Binding Actin Binding Protein Binding Lamin Binding Enzyme Binding Protein Homodimerization Activity Actin Filament Binding Cytoskeleton-nuclear Membrane Anchor Activity	Protein Binding Calmodulin Binding Adenylate Cyclase Binding Protein Kinase A Binding
	Biological Process	Nucleus Organization Golgi Organization Spermatogenesis Muscle Cell Differentiation Nuclear Matrix Anchoring At Nuclear Membrane	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Protein Kinase A Signaling Positive Regulation Of Protein Kinase A Signaling Response To Lipopolysaccharide Positive Regulation Of Tumor Necrosis Factor Production Hepatic Stellate Cell Activation Negative Regulation Of Vascular Permeability Modulation Of Chemical Synaptic Transmission Response To Electrical Stimulus Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of Hepatic Stellate Cell Migration Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Regulation Of Protein Kinase C Signaling Positive Regulation Of Oligodendrocyte Apoptotic Process
Pathways		Meiotic synapsis	RHOD GTPase cycle RHOF GTPase cycle
Drugs
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 28115744 21926972 31043756 28072414 20351715 21738484) Bipolar disorder or major depressive disorder ( 20351715) Bipolar I disorder ( 31043756) Body mass index ( 26426971) Endometriosis ( 28537267) Heel bone mineral density ( 30598549 28869591) Hip circumference adjusted for BMI ( 34021172) Post bronchodilator FEV1 ( 26634245) Tonometry ( 17903302) Uterine fibroids ( 31249589 30194396 31649266)	Alzheimer's disease progression score ( 29860282) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Chronic myeloid leukemia ( 21540461) Coronary artery disease ( 29212778) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Delirium ( 29631748) Heel bone mineral density ( 30598549) Nevus count or cutaneous melanoma ( 32341527) Refractive error ( 32231278) Type 2 diabetes ( 25760438) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		32 interacting genes: ACTC1 AKAP12 APC BDKRB2 CAPN1 CDC42 CDC5L CEP63 DISC1 DTNBP1 ECPAS EMD GPX2 IL22RA2 IYD LATS1 LINC00839 LMNA MTDH MUSK MYOM1 NDEL1 NUP43 RAET1E RAET1L SH3BP5 TNIK TP53RK ULBP1 ULBP2 USP21 ZC3H12D	9 interacting genes: ADRB2 EGFR ERBB2 FHL1 GRK2 PRKAR2A PRKCA PTEN SYNE1
Entrez ID		23345	9590
HPRD ID		09762	05263
Ensembl ID		ENSG00000131018	ENSG00000131016
Uniprot IDs		A0A0C4DG40 B4E3R1 B7Z9Y6 F8WAI0 Q8NF91	Q02952 Q86TJ9
PDB IDs		4DXR 6R15 6XF2
Enriched GO Terms of Interacting Partners?
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